NEONATAL ANTI-NGF TREATMENT REDUCES THE A-DELTA-FIBER AND C-FIBER EVOKED VASODILATOR RESPONSES IN RAT SKIN - EVIDENCE THAT NOCICEPTOR AFFERENTS MEDIATE ANTIDROMIC VASODILATATION
NEONATAL ANTI-NGF TREATMENT REDUCES THE A-DELTA-FIBER AND C-FIBER EVOKED VASODILATOR RESPONSES IN RAT SKIN - EVIDENCE THAT NOCICEPTOR AFFERENTS MEDIATE ANTIDROMIC VASODILATATION
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DOI：
10.1111/j.1460-9568.1992.tb00146.x
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发表时间：
1992-12-01
影响因子：
3.4
通讯作者：
MENDELL, LM
中科院分区：
文献类型：
--
作者：
LEWIN, GR;LISNEY, SJW;MENDELL, LM
在这里，我们已经研究了这种现象，在成年大鼠治疗postnatally与抗血清神经生长因子之间的出生后第2和14天。这种治疗迫使许多Δ伤害感受器传入呈现低阈值D-毛传入的表型（Lewin等人，J. Neurosci.，12，1896-1905，1992）。在以这种方式治疗的动物中，我们发现Adelta纤维增加皮肤血流量的能力平行下降。由C纤维刺激引起的血流量增加也减少了，但C纤维引起皮肤神经性外渗的能力没有变化。这些数据可以作为证据，在大鼠中，在皮肤Adelta纤维中，伤害感受器而不是D-毛传入能够在皮肤中产生血流变化。
Here we have examined this phenomenon in adult rats treated neonatally with antisera to nerve growth factor between postnatal days 2 and 14. This treatment forces many Adelta nociceptor afferents to take on the phenotype of low-threshold D-hair afferents (Lewin et al, J. Neurosci., 12, 1896-1905, 1992). In animals treated this way we found a parallel decrease in the ability of Adelta-fibres to increase skin blood flow. The increase in blood flow evoked by C-fibre stimulation was also reduced, but no change was seen in the ability of C-fibres to elicit neurogenic extravasation in skin. These data may be taken as evidence that in rats, amongst the cutaneous Adelta-fibres, nociceptor but not D-hair afferents are capable of producing blood flow changes in the skin.