Simple sequence repeats as a source of quantitative genetic variation
Simple sequence repeats as a source of quantitative genetic variation
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DOI：
10.1016/s0168-9525(97)01008-1
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发表时间：
1997-02-01
影响因子：
11.4
通讯作者：
Soller, M
中科院分区：
文献类型：
--
作者：
Kashi, Y;King, D;Soller, M
生物群体中的肥大性状似乎处于消除数量遗传变异的稳定选择之下，然而，实际上生物群体中所有测量的性状都继续显示出显著的数量遗传变异。这个悖论可以通过假设存在丰富的，尽管未指明的突变来源来解决，这些突变对表型有定量影响，但不会减少适应性。这样的源头真的存在吗？我们认为，它是以SSR（简单序列重复，其中人类神经退行性疾病的三联重复是一个特例）中重复数变异的形式存在的。将SSR视为数量突变的主要来源对于理解进化适应的分子过程具有广泛的意义，包括突变过程本身的进化控制。
Mast traits in biological populations appear to be under stabilizing selection which acts to eliminate quantitative genetic variation Yet, virtually all measured traits in biological populations continue to show significant quantitative genetic variation. The paradox can be resolved by postulating the existence of an abundant, though unspecified, source of mutations that has quantitative effects on phenotype, bid noes not reduce fitness. Does such a source actually exist? We propose that it noes, In the form of repeat-number variation in SSRs (simple sequence repeats, of which the triplet repeats of human neurodegenerative diseases are a special case). Viewing SSRs as a major source of quantitative mutation has broad implications for understanding molecular processes of evolutionary adaptation, including the evolutionary control of the mutation process itself.