Microfilament-coordinated adhesion dynamics drives single cell migration and shapes whole tissues.
Microfilament-coordinated adhesion dynamics drives single cell migration and shapes whole tissues.
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DOI：
10.12688/f1000research.10356.1
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Vicente-Manzanares M
中科院分区：
文献类型：
--
作者：
Aguilar-Cuenca R;Llorente-Gonzalez C;Vicente C;Vicente-Manzanares M
细胞与基质和/或其他细胞的粘附是细胞迁移的关键步骤。虽然在单独迁移的细胞（例如免疫细胞）中至关重要，但在细胞集体迁移中尤其重要，在集体迁移中，细胞在定向移动时保持与邻近细胞的接触。粘附协调在生理环境（例如，器官发生过程）和病理（例如，肿瘤转移）中都是至关重要的。在这篇综述中，我们讨论了在集体细胞迁移过程中对细胞-细胞和细胞-基质粘附的协调调节的需要。我们强调肌动蛋白细胞骨架作为钙粘蛋白和整合素为基础的黏着的细胞内整合者的作用，以及力学在黏着接触的维持、加强和周转中的新兴作用。在了解钙粘蛋白和整合素粘附的几个组成部分的机械调节方面的最新进展使我们能够重新审视在突出过程中控制粘附接合程度的粘附离合器假说。最后，我们简要概述了这些发现在使用单细胞和集体细胞迁移的更多生理三维模型时的主要影响。
Cell adhesion to the substratum and/or other cells is a crucial step of cell migration. While essential in the case of solitary migrating cells (for example, immune cells), it becomes particularly important in collective cell migration, in which cells maintain contact with their neighbors while moving directionally. Adhesive coordination is paramount in physiological contexts (for example, during organogenesis) but also in pathology (for example, tumor metastasis). In this review, we address the need for a coordinated regulation of cell-cell and cell-matrix adhesions during collective cell migration. We emphasize the role of the actin cytoskeleton as an intracellular integrator of cadherin- and integrin-based adhesions and the emerging role of mechanics in the maintenance, reinforcement, and turnover of adhesive contacts. Recent advances in understanding the mechanical regulation of several components of cadherin and integrin adhesions allow us to revisit the adhesive clutch hypothesis that controls the degree of adhesive engagement during protrusion. Finally, we provide a brief overview of the major impact of these discoveries when using more physiological three-dimensional models of single and collective cell migration.