Serotonergic modulation of crayfish hindgut.
Serotonergic modulation of crayfish hindgut.
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小龙虾后肠的血清素调节。
DOI：
10.1086/bblv217n1p50
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Edwards,DonaldH
中科院分区：
文献类型：
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作者：
Musolf,BarbaraE;Spitzer,Nadja;Antonsen,BrianL;Edwards,DonaldH
螯虾后肠是一种形态分化的管，其在肌肉和腺体的分布、收缩特性、5-HT能神经支配、5-HT受体表达模式以及对5-HT（5-HT）的敏感性方面沿其长度沿着变化。解剖学上的差异将后肠分为沿着其长度的五个不同部分。由离体后肠产生的自发性搏动性收缩沿着前后轴的力量减小，频率沿着增加。后肠的中枢输入来自终末腹神经节中的一大簇5-HT免疫反应神经元，它们在后肠上形成一个大的神经丛。5-HT 1 α和5-HT 2 β受体沿着肠分布不同，与纵肌和环肌以及5-HT免疫反应神经元的轴突侧支有关。将30 nmol l− 1至1 μmol l−15-HT应用于后肠的嘴部、中部或尾部，产生张力变化，其随浓度和截面而变化。5-HT还在后肠中引起反蠕动波。这些结果表明，5-HT是一个重要的神经调质启动收缩和协调活动的不同功能隔室沿着嘴尾轴的后肠。
The crayfish hindgut is a morphologically differentiated tube that varies along its length in the distribution of muscles and glands, contractile properties, serotonergic innervation, patterns of 5-HT receptor expression, and sensitivity to serotonin (5-HT). Anatomical differences divide the hindgut into five distinct segments along its length. Spontaneous pulsatile contractions produced by the isolated hindgut decrease in force and increase in frequency along the anterior-posterior axis. Central input to the hindgut comes from a large cluster of 5-HT-immunoreactive neurons in the terminal abdominal ganglion that form a large nerve plexus on the hindgut. 5-HT1αand 5-HT2βreceptors vary in their distribution along the hindgut, and are associated with longitudinal and circular muscles and with axon collaterals of the 5-HT-immunoreactive neurons. Application of 30 nmol l−1to 1 μmol l−15-HT to rostral, middle, or caudal sections of hindgut produced tension changes that varied with the concentration and section. 5-HT also initiated antiperistaltic waves in the posterior hindgut. These results indicate that 5-HT is an important neuromodulator for initiating contractions and coordinating activity in the different functional compartments along the rostral-to-caudal axis of the hindgut.