Mesenchymal stem cells (MSCs) as skeletal therapeutics - an update.
Mesenchymal stem cells (MSCs) as skeletal therapeutics - an update.
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DOI：
10.1186/s12929-016-0254-3
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发表时间：
2016-04-16
影响因子：
11
通讯作者：
Khan AM
中科院分区：
文献类型：
--
作者：
Saeed H;Ahsan M;Saleem Z;Iqtedar M;Islam M;Danish Z;Khan AM
间充质干细胞不仅有望治疗多种先天性和后天性骨退行性疾病，还可以修复和再生病态骨组织。多项证据表明，利用间充质干细胞在骨骼疾病和骨骼组织修复/再生方面具有良好的临床效果。在这种情况下，自体和同种异体细胞转移选项都已被利用。研究表明，间充质干细胞可以通过与自体血浆/血清混合单独移植，也可以通过加载到修复/诱导支持性可吸收支架上进行移植。因此，本综述旨在强调间充质干细胞在骨骼疾病和骨骼组织再生治疗中的广泛相关临床治疗选择。此外，在骨骼疾病和再生切片中，仅讨论早期和最近的临床前证据，然后讨论所有相关的临床研究。此外，还讨论了间充质干细胞提供的密切的移植后治疗机制。尽管如此，在临床上自信地使用间充质干细胞治疗骨骼疾病和修复还远不是一种成熟的治疗选择，因此，还讨论了所带来的挑战和未来的方向。重要的是，为了在所有情况下保持一致，整个审查过程中都使用术语 MSC。
Mesenchymal stem cells hold the promise to treat not only several congenital and acquired bone degenerative diseases but also to repair and regenerate morbid bone tissues. Utilizing MSCs, several lines of evidences advocate promising clinical outcomes in skeletal diseases and skeletal tissue repair/regeneration. In this context, both, autologous and allogeneic cell transfer options have been utilized. Studies suggest that MSCs are transplanted either alone by mixing with autogenous plasma/serum or by loading onto repair/induction supportive resorb-able scaffolds. Thus, this review is aimed at highlighting a wide range of pertinent clinical therapeutic options of MSCs in the treatment of skeletal diseases and skeletal tissue regeneration. Additionally, in skeletal disease and regenerative sections, only the early and more recent preclinical evidences are discussed followed by all the pertinent clinical studies. Moreover, germane post transplant therapeutic mechanisms afforded by MSCs have also been conversed. Nonetheless, assertive use of MSCs in the clinic for skeletal disorders and repair is far from a mature therapeutic option, therefore, posed challenges and future directions are also discussed. Importantly, for uniformity at all instances, term MSCs is used throughout the review.