THE INTRACRANIAL TOPOGRAPHY OF THE P3 EVENT-RELATED POTENTIAL ELICITED DURING AUDITORY ODDBALL
THE INTRACRANIAL TOPOGRAPHY OF THE P3 EVENT-RELATED POTENTIAL ELICITED DURING AUDITORY ODDBALL
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DOI：
10.1016/0013-4694(90)90018-f
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发表时间：
1990-09-01
期刊：
影响因子：
--
通讯作者：
CHAUVEL, P
中科院分区：
文献类型：
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作者：
SMITH, ME;HALGREN, E;CHAUVEL, P
为了分离主要负责产生头皮记录的P3（或P300）的神经活动的解剖学位点，事件相关电位（ERP）的地形图在听觉oddball任务期间引起的额叶，顶叶和颞叶的内侧到外侧的方面进行比较，在10例癫痫患者进行立体脑电图癫痫发作定位。从这些领域中的每一个都获得了当地企业资源规划生成的证据。小振幅P3型电位有时被观察到在额叶记录触点的极性反转。在顶下小叶（IPL）的外侧新皮质中观察到大幅度正极性P3型成分，其在更前部、后部、上级、下部和内侧记录接触处的幅度迅速衰减。大振幅极性反转P3型成分也被观察到高度本地化的颞叶电极的海马接触。这些数据进行了讨论的背景下，其他最近的研究病变的影响，头皮地形，和颅内记录，它的结论是，在IPL中产生的活动可能会作出重大贡献的头皮记录的P3，从这些其他来源的贡献较小。最后，P3与N2（或N200）和慢波（SW）颅内分布之间的显著地形差异表明，这些成分的发生器并不相同。
In order to isolate the anatomical locus of neural activity primarily responsible for generating the scalp-recorded P3 (or P300), the topography of event-related potentials (ERPs) elicited during an auditory oddball task was compared between medial-to-lateral aspects of the frontal, parietal, and temporal lobes in 10 epileptic patients undergoing stereoelectroencephalography for seizure localization. Evidence of local ERP generation was obtained from each of these areas. Small amplitude P3-type potentials were sometimes observed to invert polarity across recording contacts in the frontal lobe. Large amplitude positive polarity P3-type components were observed in the lateral neocortex of the inferior parietal lobule (IPL), that rapidly attenuated in amplitude at more anterior, posterior, superior, inferior, and medial recording contacts. Large amplitude polarity inverting P3-type components were also observed to be highly localized to hippocampal contacts of temporal lobe electrodes. These data are discussed in the context of other recent studies of lesion effects, scalp topography, and intracranial recordings, and it is concluded that activity generated in the IPL is likely to make the major contribution to the scalp-recorded P3, with smaller contributions from these other sources. Finally, salient topographical differences between the intracranial distribution of the P3 and those of the N2 (or N200) and slow wave (SW) suggest that the generators of these components are not identical.