The role of the complement system in traumatic brain injury: a review.
The role of the complement system in traumatic brain injury: a review.
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补体系统在创伤性脑损伤中的作用：综述。
DOI：
10.1186/s12974-018-1066-z
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发表时间：
2018-01-22
影响因子：
9.3
通讯作者：
Zaben M
中科院分区：
文献类型：
--
作者：
Hammad A;Westacott L;Zaben M
创伤性脑损伤（TBI）是西方世界致残和死亡的重要原因。虽然最初的损伤持续导致损害，但随后的继发性级联反应被认为是随后结果的重要决定因素。与继发性损伤相关的变化直到级联反应开始后一段时间才变得不可逆。这可能为旨在改善TBI后结局的治疗干预提供了机会之窗。继发性损伤的一个突出贡献者是多方面的炎症反应。补体系统在这种炎症反应中起着显着的作用;然而，它在TBI继发性损伤的背景下经常被忽视。补体系统在未受损的中枢神经系统（CNS）中具有稳态功能，在神经发育中起作用，并且在完全发育的CNS中具有保护功能，包括保护免受感染和炎症。在中枢神经系统损伤的情况下，它可能具有许多有害作用，其证据主要不仅来自动物模型，而且在较小程度上来自人类尸检研究。与此形成鲜明对比的是，补体还可以促进CNS损伤后的神经发生和可塑性。本文通过临床和动物实验研究，探讨补体系统在脑外伤继发性损伤中的作用。我们研究是否特定的补体激活途径发挥更突出的作用，在TBI比其他人。我们还探讨了补体在TBI后神经保护和CNS修复/再生中的潜在作用。最后，我们强调了针对补体系统的治疗潜力，在TBI的背景下，并指出某些领域，未来的研究是必要的。
Traumatic brain injury (TBI) is an important cause of disability and mortality in the western world. While the initial injury sustained results in damage, it is the subsequent secondary cascade that is thought to be the significant determinant of subsequent outcomes. The changes associated with the secondary injury do not become irreversible until some time after the start of the cascade. This may present a window of opportunity for therapeutic interventions aiming to improve outcomes subsequent to TBI. A prominent contributor to the secondary injury is a multifaceted inflammatory reaction. The complement system plays a notable role in this inflammatory reaction; however, it has often been overlooked in the context of TBI secondary injury. The complement system has homeostatic functions in the uninjured central nervous system (CNS), playing a part in neurodevelopment as well as having protective functions in the fully developed CNS, including protection from infection and inflammation. In the context of CNS injury, it can have a number of deleterious effects, evidence for which primarily comes not only from animal models but also, to a lesser extent, from human post-mortem studies. In stark contrast to this, complement may also promote neurogenesis and plasticity subsequent to CNS injury. This review aims to explore the role of the complement system in TBI secondary injury, by examining evidence from both clinical and animal studies. We examine whether specific complement activation pathways play more prominent roles in TBI than others. We also explore the potential role of complement in post-TBI neuroprotection and CNS repair/regeneration. Finally, we highlight the therapeutic potential of targeting the complement system in the context of TBI and point out certain areas on which future research is needed.
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DOI：
10.4049/jimmunol.0903678
发表时间：
2010-11-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Amara U;Flierl MA;Rittirsch D;Klos A;Chen H;Acker B;Brückner UB;Nilsson B;Gebhard F;Lambris JD;Huber-Lang M
通讯作者：
Huber-Lang M
影响因子：
4.2
作者：
Bellander, BM;Singhrao, SK;Svensson, M
通讯作者：
Svensson, M
T 辅助细胞 1 免疫需要 CD4⁺ T 细胞中补体驱动的 NLRP3 炎性体活性。
DOI：
10.1126/science.aad1210
发表时间：
2016-06-17
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Arbore G;West EE;Spolski R;Robertson AAB;Klos A;Rheinheimer C;Dutow P;Woodruff TM;Yu ZX;O'Neill LA;Coll RC;Sher A;Leonard WJ;Köhl J;Monk P;Cooper MA;Arno M;Afzali B;Lachmann HJ;Cope AP;Mayer-Barber KD;Kemper C
通讯作者：
Kemper C
影响因子：
9.3
作者：
Colton CA;Mott RT;Sharpe H;Xu Q;Van Nostrand WE;Vitek MP
通讯作者：
Vitek MP
DOI：
10.1523/jneurosci.3932-10.2011
发表时间：
2011-03-02
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Benoit ME;Tenner AJ
通讯作者：
Tenner AJ