Prior stress experience modulates social preference for stressed conspecifics in male rats
Prior stress experience modulates social preference for stressed conspecifics in male rats
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DOI：
10.1016/j.neulet.2021.136253
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发表时间：
2021-09
影响因子：
2.5
通讯作者：
Michimasa Toyoshima;Koshiro Mitsui;Kazuo Yamada
中科院分区：
文献类型：
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作者：
Michimasa Toyoshima;Koshiro Mitsui;Kazuo Yamada
成年雄性大鼠倾向于避开处于困境中的成年同种动物。在这项研究中，我们使用社会情感偏好(SAP)测试，询问先前的压力经历是否会调节对压力同种的社会偏好。雄性Long-Evans成年大鼠分为休克组和非休克组。休克组大鼠在SAP实验前24 h进行急性足底电击(1.0 mA，5次S持续时间1次×2次)。在SAP测试期间，实验大鼠被放置在一个竞技场中，其中一只大鼠在SAP测试前立即接受足部电击，其中一只在两端被呈现并允许自由探索5min。我们测量了对每个同种动物的嗅觉行为，作为社会偏好的指标。未休克的成年大鼠回避应激，而休克大鼠接近时，应激比非应激更接近特定的应激状态。这些结果表明，先前的应激促进了成年雄性大鼠对应激同种动物的社会偏好。
Adult male rats tend to avoid adult conspecifics in distress. In this study, we asked whether prior stress experience would modulate social preference for a stressed conspecific using a social affective preference (SAP) test. Male Long-Evans adult rats were assigned to the shocked and non-shocked groups. In the shocked group, rats were acutely subjected to foot shocks (1.0 mA, 5 s duration × 2) 24 h before the SAP test. During the SAP test, the experimental rats were placed in an arena where two adult conspecific stimuli, one of which received the foot shocks immediately before the SAP test, were presented at both ends and allowed to explore freely for 5 min. We measured sniffing behavior toward each conspecific as an index of social preference. Non-shocked adult rats avoided, while shocked rats approached, the stressed conspecifics more than the non-stressed ones. These results suggest that prior stress promotes social preference for a stressed conspecific in adult male rats.