Biological activity of FGF-23 fragments
Biological activity of FGF-23 fragments
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DOI：
10.1007/s00424-007-0231-5
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发表时间：
2007-07-01
影响因子：
4.5
通讯作者：
Kumar, Rajiv
中科院分区：
文献类型：
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作者：
Berndt, Theresa J.;Craig, Theodore A.;Kumar, Rajiv
完整的、全长的成纤维细胞生长因子-23(成纤维细胞生长因子-23)的磷酸活性已被很好地记录下来。成纤维细胞生长因子-23以完整的蛋白质和全长蛋白质的蛋白分解产生的片段的形式循环。为了评估成纤维细胞生长因子-23的短片段是否是磷酸的，我们比较了急性等摩尔输注全长的成纤维细胞生长因子-23和不同的成纤维细胞生长因子-23片段的羧基末端与氨基酸176的效果。在大鼠中，静脉注射全长的成纤维细胞生长因子-23和成纤维细胞生长因子-23 176-251显著增加了分数磷酸盐排泄量(FEPI)，从14+/-3增加到32+/-5%和15+/-2增加到33+/-2%(p
The phosphaturic activity of intact, full-length, fibroblast growth factor-23 (FGF-23) is well documented. FGF-23 circulates as the intact protein and as fragments generated as the result of proteolysis of the full-length protein. To assess whether short fragments of FGF-23 are phosphaturic, we compared the effect of acute, equimolar infusions of full-length FGF-23 and various FGF-23 fragments carboxyl-terminal to amino acid 176. In rats, intravenous infusions of full-length FGF-23 and FGF-23 176-251 significantly and equivalently increased fractional phosphate excretion (FE Pi) from 14 +/- 3 to 32 +/- 5% and 15 +/- 2 to 33 +/- 2% (p