Combining Magnetic Resonance Imaging with Photothermal Therapy of CuS@BSA Nanoparticles for Cancer Theranostics
Combining Magnetic Resonance Imaging with Photothermal Therapy of CuS@BSA Nanoparticles for Cancer Theranostics
复制标题
DOI：
10.1021/acsanm.8b00410
复制
发表时间：
2018-05-01
影响因子：
5.9
通讯作者：
Jia, Nengqin
中科院分区：
文献类型：
--
作者：
Chu, Zhongyun;Wang, Zhiming;Jia, Nengqin
肿瘤的治疗一直受到广大科研人员的广泛关注。将磁共振成像 (MRI) 与光热疗法 (PTT) 相结合，使癌症治疗诊断更加高效和准确。在此，我们通过一种简便的一锅法、环保且用户友好的策略合成了平均粒径约为16.5 nm的CuS@BSA纳米颗粒，发现它具有很强的近红外吸收特性和磁共振成像能力，因此可以用作癌症治疗诊断的多功能试剂。体外毒性研究表明，低毒性的CuS@BSA纳米颗粒可以在980 nm近红外激光下有效杀死癌细胞。此外，与临床广泛使用的试剂Magnevist (r(1) = 3.13 mM(-1).s(-1))相比，它们表现出一定的弛豫度值(r(1) = 0.26 mM(-1).s(-1))。由此产生的 CuS@BSA 纳米粒子产物具有磁共振成像 (MRI) 和光热治疗能力，可以代表癌症治疗诊断学的一种潜在候选者。
The treatment of tumors has been a wide concern by a large number of scientific researchers. Combining magnetic resonance imaging (MRI) with photothermal therapy (PTT) enables cancer theranostics to be more efficient and accurate. Herein, we synthesized CuS@BSA nanoparticles with an average grain diameter of about 16.5 nm through a facile one-pot eco-friendly and user-friendly strategy and it was found to have strong near-infrared absorption property and magnetic resonance imaging ability so that it can be utilized as a multifunctional agent for cancer theranostic. The in vitro toxicity study showed that CuS@BSA nanoparticles with low toxicity could kill cancer cells with the 980 nm NIR laser effectively. Furthermore, they exhibit a certain value of relaxivity (r(1) = 0.26 mM(-1).s(-1)) compared to that of clinically widely used reagent Magnevist (r(1) = 3.13 mM(-1).s(-1)). The resulting product of CuS@BSA nanoparticles with their magnetic resonance imaging (MRI) and photothermal therapeutic capabilities could represent a kind of potential candidate for cancer theranostics.