Mitochondrial metabolism and the control of vascular smooth muscle cell proliferation.
Mitochondrial metabolism and the control of vascular smooth muscle cell proliferation.
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DOI：
10.3389/fcell.2014.00072
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发表时间：
2014
影响因子：
5.5
通讯作者：
Mellado R
中科院分区：
文献类型：
--
作者：
Chiong M;Cartes-Saavedra B;Norambuena-Soto I;Mondaca-Ruff D;Morales PE;García-Miguel M;Mellado R
血管平滑肌细胞(VSMCs)的分化和去分化是血管发育的重要过程。VSMC在血管壁具有生物合成、增殖和收缩作用。VSMC分化状态的改变在动脉粥样硬化、高血压和血管狭窄等多种心血管疾病的发病机制中起着关键作用。本文对VSMC增殖调控的分子机制，尤其是线粒体代谢的研究现状进行了综述。线粒体的活性可以通过调节线粒体的动力学，即线粒体的融合和分裂，以及通过与内质网(ER)的相互作用来调节线粒体的钙处理来控制。丝裂蛋白-2是一种与线粒体融合和线粒体-内质网相互作用相关的小GTP酶，它的失调可以触发VSMC增殖和线粒体功能的改变。有几条证据表明线粒体代谢与VSMC增殖的控制有关，这表明在血管疾病的治疗中有一个新的领域需要探索。
Differentiation and dedifferentiation of vascular smooth muscle cells (VSMCs) are essential processes of vascular development. VSMC have biosynthetic, proliferative, and contractile roles in the vessel wall. Alterations in the differentiated state of the VSMC play a critical role in the pathogenesis of a variety of cardiovascular diseases, including atherosclerosis, hypertension, and vascular stenosis. This review provides an overview of the current state of knowledge of molecular mechanisms involved in the control of VSMC proliferation, with particular focus on mitochondrial metabolism. Mitochondrial activity can be controlled by regulating mitochondrial dynamics, i.e., mitochondrial fusion and fission, and by regulating mitochondrial calcium handling through the interaction with the endoplasmic reticulum (ER). Alterations in both VSMC proliferation and mitochondrial function can be triggered by dysregulation of mitofusin-2, a small GTPase associated with mitochondrial fusion and mitochondrial–ER interaction. Several lines of evidence highlight the relevance of mitochondrial metabolism in the control of VSMC proliferation, indicating a new area to be explored in the treatment of vascular diseases.
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