CFTR and its key role in in vivo resting and luminal acid‐induced duodenal HCO3− secretion
CFTR and its key role in in vivo resting and luminal acid‐induced duodenal HCO3− secretion
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DOI：
10.1111/j.1748-1716.2008.01854.x
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发表时间：
2008-08
影响因子：
6.3
通讯作者：
Anurag Kumar Singh;Markus Sjöblom;Wen Zheng;Anja Krabbenhöft;B. Riederer;B. Rausch;Michael P. Manns;Manoocher Soleimani;Ursula Seidler
中科院分区：
文献类型：
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作者：
Anurag Kumar Singh;Markus Sjöblom;Wen Zheng;Anja Krabbenhöft;B. Riederer;B. Rausch;Michael P. Manns;Manoocher Soleimani;Ursula Seidler
背景和目标：我们研究了最近发现的绒毛表达的阴离子交换剂Slc26a6（PAT1）和主要表达的囊性纤维化跨膜调节因子（CFTR）在体内基础和酸刺激的小鼠十二指肠HCO3−分泌中的作用，以及血液HCO3−浓度对两者的影响。
Background and aims: We investigated the role of the recently discovered, villous‐expressed anion exchanger Slc26a6 (PAT1) and the predominantly crypt‐expressed cystic fibrosis transmembrane regulator (CFTR) in basal and acid‐stimulated murine duodenal HCO3− secretion in vivo, and the influence of blood HCO3− concentration on both.