Training-induced alterations in fat and carbohydrate metabolism during exercise in elderly subjects.
Training-induced alterations in fat and carbohydrate metabolism during exercise in elderly subjects.
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老年受试者运动期间训练引起的脂肪和碳水化合物代谢变化。
DOI：
10.1152/ajpendo.1998.274.5.e785
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Klein,S
中科院分区：
文献类型：
--
作者：
Sial,S;Coggan,AR;Hickner,RC;Klein,S
与年轻人相比，在相同的绝对或相对强度下进行耐力运动时，老年人的脂肪氧化较低。我们评估了6名老年男性和女性（74 ± 2岁）在60分钟中等强度运动[训练前峰值耗氧量（V steco 2 peak）的50%]期间进行16周耐力训练对脂肪和葡萄糖代谢的影响。训练导致meanV steco 2峰值增加21%。运动期间脂肪氧化的平均速率在训练后（221 ± 28 μmol/min）大于训练前（166 ± 17 μmol/min）（P= 0.002），运动期间碳水化合物氧化的平均速率在训练后（3，180 ± 461 μmol/min）低于训练前（3，937 ± 483 μmol/min）（P= 0.003）。训练没有引起甘油出现率（Ra），游离脂肪酸（FFA）Ra和FFA在运动过程中消失率的显着变化。运动后血糖（1,027 ± 95 μmol/min）低于运动前（1,157 ± 69 μmol/min）（P= 0.01）。这些结果表明，16周的耐力训练增加脂肪氧化，而没有显着变化的脂肪分解（甘油Ra）或FFA的可用性（FFA Ra）在老年受试者的运动。因此，在运动过程中，训练诱导的脂肪氧化的增加可能与骨骼肌脂肪酸代谢的改变有关。
Compared with young adults, fat oxidation is lower in elderly persons during endurance exercise performed at either the same absolute or relative intensity. We evaluated the effect of 16 wk of endurance training on fat and glucose metabolism during 60 min of moderate intensity exercise [50% of pretraining peak oxygen consumption (V˙o2 peak)] in six elderly men and women (74 ± 2 yr). Training caused a 21% increase in meanV˙o2 peak. The average rate of fat oxidation during exercise was greater after (221 ± 28 μmol/min) than before (166 ± 17 μmol/min) training (P= 0.002), and the average rate of carbohydrate oxidation during exercise was lower after (3,180 ± 461 μmol/min) than before (3,937 ± 483 μmol/min) training (P= 0.003). Training did not cause a significant change in glycerol rate of appearance (Ra), free fatty acid (FFA) Ra, and FFA rate of disappearance during exercise. However, glucose Raduring exercise was lower after (1,027 ± 95 μmol/min) than before (1,157 ± 69 μmol/min) training (P= 0.01). These results demonstrate that a 16-wk period of endurance training increases fat oxidation without a significant change in lipolysis (glycerol Ra) or FFA availability (FFA Ra) during exercise in elderly subjects. Therefore, the training-induced increase in fat oxidation during exercise is likely related to alterations in skeletal muscle fatty acid metabolism.