Elevated preoperative neutrophil to lymphocyte ratio predicts risk of recurrence following curative resection for stage IIA colon cancer
Elevated preoperative neutrophil to lymphocyte ratio predicts risk of recurrence following curative resection for stage IIA colon cancer
复制标题
DOI：
10.1007/s00384-010-1052-0
复制
发表时间：
2010-12-01
影响因子：
2.8
通讯作者：
Pan, Zhi-Zhong
中科院分区：
文献类型：
--
作者：
Ding, Pei-Rong;An, Xin;Pan, Zhi-Zhong
背景和目的II期结肠癌的辅助化疗仍有争议，但可考虑用于高危患者。最近的研究表明，中性粒细胞与淋巴细胞比率（NLR）升高，NLR是晚期结直肠癌患者预后较差的因素，也是化疗反应的预测因子。本研究的目的是评估NLR是否可预测IIA期结肠癌患者的复发风险。方法我们回顾性分析了2002年至2006年NLR期间141例仅接受根治性手术治疗的IIA期结肠癌患者的人口统计学、临床、组织病理学，单因素和多因素分析确定与无复发生存期（RFS）相关的预后因素结果考克斯回归分析显示，NLR> 4（危险比4 88，P
Background and Objectives Adjuvant chemotherapy for stage II colon cancer remains controversial but may be considered for patients with high-risk features Recent studies have shown that elevated neutrophil to lymphocyte ratio (NLR) is a worse prognostic factor and a predictor of response to chemotherapy in patients with advanced colorectal cancer The purpose of this study was to evaluate whether NLR predicts risk of recurrence in patients with stage IIA colon cancer undergoing curative resection without adjuvant chemotherapyMethods We retrospectively reviewed 141 consecutive patients with stage IIA colon cancer treated with curative surgery alone from 2002 to 2006 NLR, as well as demographics, clinical, histopathologic, and laboratory data were analyzed Univariate and multivariate analyses were conducted to identify prognostic factors associated with recurrent-free survival (RFS)Results Cox's regression analysis demonstrated that elevated NLR (>4) (hazard ratio, 4 88, P