Development of distortion product otoacoustic emissions in C57BL/6J mice
Development of distortion product otoacoustic emissions in C57BL/6J mice
复制标题
DOI：
10.1080/14992020902858959
复制
发表时间：
2009-01-01
影响因子：
2.7
通讯作者：
Ikeda, Katsuhisa
中科院分区：
文献类型：
--
作者：
Narui, Yuya;Minekawa, Akira;Ikeda, Katsuhisa
失真产物耳声排放（DPOAE）已用于检查大鼠和沙鼠的听力发展。但是，没有关于小鼠听力发作的DPOAE测量的报告。组装商业上可用的组件并进行了调整，以提供合适的探针麦克风和声音输送系统，以测量开发C57BL/6J小鼠的DPOAE。此外，将DPOAE数据与听觉脑干响应（ABR）的发现进行了比较。从出生后11天开始以8 kHz的速度获得DPOAE，从12天为20 kHz，从13天到30 kHz。在8和20 kHz时获得了21天的成年DPOAE模式，在30 kHz时获得了28天。另一方面，12至36 kHz的ABR阈值出现在11到12天之间，并在14天后饱和。基于这些数据，小鼠中可测量的DPOAE的发作早于大鼠和沙鼠。小鼠中DPOAE的成熟在高频范围内以较低的频率开始。另外，ABR阈值比DPOAE早到成熟。
Distortion product otoacoustic emissions (DPOAEs) have been used to examine the development of hearing in the rat and gerbil. However, no reports of DPOAE measurement from the onset of hearing in mice are available. Commercially-available components were assembled and adapted to provide a suitable probe microphone and sound delivery system for measuring DPOAE in developing C57BL/6J mice. Furthermore, DPOAE data were compared with the findings of the auditory brainstem response (ABR). DPOAEs were obtained at 8 kHz from 11 days after birth, 20 kHz from 12 days, and 30 kHz from 13 days. Adult-like patterns of DPOAE were obtained 21 days at 8 and 20 kHz, and 28 days at 30 kHz. On the other hand, the ABR thresholds at 12 to 36 kHz appeared between 11 and 12 days and were saturated at 14 days. Based on these data, the onset of measureable DPOAEs in the mouse were earlier than in the rat and gerbil. The maturation of DPOAE in the mouse begins at a lower frequency in the high frequency range. In addition, the ABR threshold reached maturation earlier than DPOAE.