Renal potassium channels and their regulation.

Renal potassium channels and their regulation.
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肾钾通道及其调节。

DOI:
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发表时间:
1992
影响因子:
18.2
通讯作者:
G. Giebisch
G. Giebisch
中科院分区:
医学1区
文献类型:
--
作者:
W. Wang;H. Sackin;G. Giebisch

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Potassium channels play important roles in renal electrolyte transport, mainte­ nance of cell membrane potential, and regulation of cell volume. In the past decade, the patch-clamp technique has been extensively used to identify a variety of K channels at the apical and basolateral membranes of renal epithelia. Several of these channels are similar to the K channels of non-renal epithelia, which suggests a common evolutionary basis for K permeation across cell membranes. Although the kidney is not an excitable tissue, many renal K channels are voltage-gated, and some are even activated by membrane stretch andlor changes in cell volume. For example, calcium-dependent maxi
DOI: 10.1073/pnas.81.13.4237
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