Distinct Characteristics Between Perivascular and Subcutaneous Adipose-Derived Stem Cells

Distinct Characteristics Between Perivascular and Subcutaneous Adipose-Derived Stem Cells
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DOI：
10.2337/db20-1129
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发表时间：
2022
期刊：
Diabetes
影响因子：
--
通讯作者：
Xiang Meixiang
Xiang Meixiang
中科院分区：
--
文献类型：
--
作者：
Xie Yao;Ji Yongli;Lu Yunrui;Ma Yuankuan;Ni Hui;Shen Jian;Ma Hong;Jin Chunna;Chen Yuwen;Lin Yan;Xiang Meixiang

文献摘要

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Adipose-derived stem cells (ADSCs) can differentiate into vascular lineages and participate in vascular remod- eling. Perivascular ADSCs (PV-ADSCs) draw attention because of their unique location. The heterogeneity of subcutaneous (SUB) and abdominal ADSCs were well addressed, but PV-ADSCs’ heterogeneity has not been investigated. In this study, we applied single-cell analysis to compare SUB-ADSCs and PV-ADSCs regarding their subpopulations, functions, and cell fates. We uncovered four subpopulations of PV-ADSCs (Dpp41, Col4a21/ Icam11, Clec11a1/Cpe1, and Sult1e11 cells), among which the Clec11a+ subpopulation potentially partici- pated in and regulated PV-ADSC differentiation toward a smooth muscle cell (SMC) phenotype. Distinct charac- teristics between PV-ADSCs and SUB-ADSCs were revealed.