Predictive factors of ART adherence in people living with HIV in Guangxi, China: a retrospective cross-sectional study
Predictive factors of ART adherence in people living with HIV in Guangxi, China: a retrospective cross-sectional study
复制标题
中国广西艾滋病毒感染者抗逆转录病毒治疗依从性的预测因素：一项回顾性横断面研究。
DOI：
10.1080/09540121.2021.1967851
复制
发表时间：
2021-08-17
影响因子：
1.7
通讯作者：
Ning, Chuanyi
中科院分区：
文献类型：
--
作者：
Lai, Jingzhen;Jiang, Zhongsheng;Ning, Chuanyi
坚持抗逆转录病毒治疗（ART）是提高免疫力和降低艾滋病毒感染者（PLWH）发病率和死亡率的先决条件。为了描述艾滋病病毒感染者的抗逆转录病毒治疗依从性和相关因素，招募了1998年至2013年在柳州开始抗逆转录病毒治疗的患者。分析社会人口学特征、HIV感染相关特征和临床试验结果。采用描述性分析和多水平分析方法，探讨影响柳州市艾滋病病毒携带者抗逆转录病毒治疗依从性的因素。本研究共招募了8433例患者。1998 - 2013年柳州市艾滋病病毒感染者中，抗逆转录病毒治疗依从率为84.9%。女性、ART开始前WHO临床分期III或IV、较长的治疗时间和较高的甘油三酯与ART依从性呈正相关。同时，静脉吸毒、合并结核感染和其他机会性感染与ART依从性呈负相关。应采取措施，提高男性、通过静脉注射毒品感染艾滋病毒、同时感染结核病和其他机会性感染的艾滋病毒携带者的抗逆转录病毒治疗依从性。
Adherence to antiretroviral therapy (ART) is a prerequisite to improve immunity and reduce the morbidity and mortality of people living with HIV (PLWH). To describe ART adherence and associated factors among PLWH, patients who initiated ART in Liuzhou between 1998 and 2013 were recruited. Socio-demographic characteristics, HIV infection-related characteristics and clinical tests were analyzed. Both descriptive and multi-level analyses were used to explore factors related to ART adherence of PLWH who initiated ART in Liuzhou. A total of 8433 patients were recruited in this study. The rate of adherence to ART was 84.9% in PLWH who initiated ART in Liuzhou between 1998 and 2013. The female sex, WHO clinical stage III or IV before ART initiation, longer treatment duration and higher triglyceride were positively associated with ART adherence. Meanwhile, HIV acquired by intravenous drug use, co-infection with tuberculosis and other opportunistic infections were negatively associated with ART adherence. Measures should be adopted to improve the ART adherence of PLWH who are male, acquired HIV by intravenous drug use, and are co-infected with tuberculosis and other opportunistic infections.