P16-positive secondary tongue squamous cell carcinoma following allogeneic hematopoietic stem cell transplantation: A case report and literature review.
P16-positive secondary tongue squamous cell carcinoma following allogeneic hematopoietic stem cell transplantation: A case report and literature review.
复制标题
异基因造血干细胞移植后P16阳性继发性舌鳞状细胞癌：病例报告及文献复习。
DOI：
10.1016/j.oraloncology.2021.105399
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发表时间：
2021-06
期刊：
影响因子：
4.8
通讯作者：
Renchuan Tao
中科院分区：
文献类型：
--
作者：
Tiantian Wu;Zhenmin Liu;Xiangzhi Yong;Guocheng Mei;Qiaozhi Jiang;Meifei Fang;Ping Li;Zhongming Zhang;Renchuan Tao
异基因造血干细胞移植(allo-HSCT)作为一种提高恶性血液病患者存活率的方法，已越来越多地被用于治疗。然而，异基因造血干细胞移植后一些潜在的严重并发症，包括移植物抗宿主病、移植物衰竭、感染、终末器官毒性和继发性恶性肿瘤，将决定造血重建的成功。在这里，我们描述了一例p16阳性的舌鳞状细胞癌(TSCC)患者接受异体造血干细胞移植后。一位62岁的男性患者曾因急性淋巴细胞白血病(AML)接受过allo-HSCT，他的舌背出现侵蚀，周围有多个白色斑块，与口腔慢性移植物抗宿主病(CGVHD)相容。随诊时，右侧舌背表面出现一圆形的侵蚀性病变。病变活检证实为早期侵袭性TSCC(T2N0M0)。停用免疫抑制剂后行舌部分切除术和舌再造术。免疫组织化学(IHC)染色p16和Ki-67阳性，提示可能是活动性人乳头瘤病毒(HPV)感染。术后6个月，患者无转移或复发迹象，也无口腔移植物抗宿主病进展。
As a method to improve the survival rate of patients with hematological malignancies, allogeneic hematopoietic stem cell transplantation (allo-HSCT) has increasingly been used for treatment. However, some potentially serious complications after allo-HSCT, including graft-versus-host disease, graft failure, infection, end-organ toxicity, and secondary malignancies, will determine the success of hematopoietic reconstitution. Here, we describe a case of a patient with p16-positive tongue squamous cell carcinoma (TSCC) following allo-HSCT. A 62-year-old man who had previously received allo-HSCT due to acute lymphocytic leukemia (AML) presented with erosions on the back of the tongue surrounded by multiple white patches, which were compatible with oral chronic graft-versus-host disease (cGVHD). During follow-up, a circular-like erosive lesion appeared on the right dorsal surface of the tongue. Biopsy of this lesion confirmed early invasive TSCC (T2N0M0). Partial glossectomy and tongue reconstruction were performed after cessation of immunosuppressants. Immunohistochemical (IHC) staining was positive for p16 and ki-67, suggesting a probable active human papillomavirus (HPV) infection. Six months after surgery, the patient showed no signs of metastasis or recurrence nor progression of oral GVHD.