GENETIC-EVIDENCE FOR THE IMPORTANCE OF INTERRUPTED FEEDING BY MOSQUITOS IN THE TRANSMISSION OF MALARIA
GENETIC-EVIDENCE FOR THE IMPORTANCE OF INTERRUPTED FEEDING BY MOSQUITOS IN THE TRANSMISSION OF MALARIA
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DOI：
10.1016/0035-9203(91)90217-m
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发表时间：
1991-07-01
影响因子：
2.2
通讯作者：
MCBRIDE, JS
中科院分区：
文献类型：
--
作者：
CONWAY, DJ;MCBRIDE, JS
从17对冈比亚儿童中获得恶性疟原虫分离株，每对分离株住在同一间房子里，同时患有疟疾。先前从当地患者的大量分离株中确定了3种多态血液阶段蛋白(MSP1、MSP2和Exp-1)的等位基因血清型频率，并计算出随机对分离株包含相同基因的概率小于0.01。然而，在一年的8对家庭中有3对，在第二年的9对家庭中，有6对含有相同的恶性疟原虫基因型别，这一频率远远高于随机预期(P<；0.00005，每年)。这一发现是从单个蚊子感染不止一个人的可能贡献的角度进行讨论的。
Plasmodium falciparum isolates were obtained from 17 pairs of Gambian children, each pair living in the same house and presenting with malaria at the same time. Frequencies of allelic serotypes of 3 polymorphic blood stage proteins (MSP1, MSP2, and Exp-1) were previously determined from a large number of isolates from patients in the local area, and the probability of a random pair of isolates containing an identical genotype was calculated to be less than 0.01. However, 3 of 8 household pairs in one year, and 6 of 9 in the next year, contained identical P. falciparum genotypes, a much higher frequency than expected randomly (P < 0.00005, for each year). This finding is discussed in terms of the probable contribution of single mosquitoes infecting more than one person.