Intrinsic kinetics fluctuations as cause of growth inhomogeneity in protein crystals
Intrinsic kinetics fluctuations as cause of growth inhomogeneity in protein crystals
复制标题
内在动力学波动是蛋白质晶体生长不均匀性的原因
DOI：
10.1103/physreve.57.6979
复制
发表时间：
1998
影响因子：
2.4
通讯作者：
F. Rosenberger
中科院分区：
文献类型：
--
作者：
P. Vekilov;F. Rosenberger
本征动力学不稳定性的形式生长步骤聚束在从溶液中的蛋白质溶菌酶的结晶过程中，其特征在于在原位高分辨率光学干涉。晶体中的成分变化（条纹），这可能会降低其效用，例如，对于通过衍射方法进行的分子结构研究，通过偏振光反射显微镜进行可视化。一个时空之间的相关性建立了一系列的移动步骤束和条纹。
Intrinsic kinetics instabilities in the form of growth step bunching during the crystallization of the protein lysozyme from solution were characterized by in situ high-resolution optical interferometry. Compositional variations (striations) in the crystal, which potentially decrease its utility, e.g., for molecular structure studies by diffraction methods, were visualized by polarized light reflection microscopy. A spatiotemporal correlation was established between the sequence of moving step bunches and the striations.