THE ROLE OF ADHESION MOLECULES IN MULTIPLE-MYELOMA
THE ROLE OF ADHESION MOLECULES IN MULTIPLE-MYELOMA
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DOI：
10.3109/10428199209054904
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发表时间：
1992-10-01
影响因子：
2.6
通讯作者：
FRANKLIN, IM
中科院分区：
文献类型：
--
作者：
BARKER, HF;BALL, J;FRANKLIN, IM
直到最近，人们才认为骨髓瘤浆细胞表达很少的表面抗原。过去的两届白细胞分化抗原国际研讨会表明，骨髓瘤细胞可以表达一系列表面分子，并且很明显，其中许多分子具有粘附功能。初步观察到在人浆细胞上发现了ICAM-1 （CD54）和H-CAM (CD44)，其他抗原如N-CAM （CD56）和LFA-3 （CD58）已被证实是恶性浆细胞的特征。LFA-1 （CD11a）的表达程度有待进一步研究。似乎一些粘附结构的丧失可能与恶性肿瘤和浆细胞白血病的增加有关。目前很少有关于这些分子功能的研究，尽管同型黏附似乎发生了，这些研究很可能会揭示骨髓瘤的发病机制。
Human myeloma plasma cells had been considered to express few surface antigens until recently. The past two International Workshops on Leucocyte Differentiation Antigens have shown that myeloma cells can express a range of surface molecules, and it has become clear that many of these have adhesive functions. The identification of ICAM-1 (CD54) and H-CAM (CD44) on human plasma cells was the initial observation, and other antigens such as N-CAM (CD56) and LFA-3 (CD58) have been confirmed as features of malignant plasma cells in particular. The degree of expression of LFA-1 (CD11a) remains to be characterised fully. It seems probable that the loss of some adhesion structures may be associated with increased malignancy and plasma cell leukaemia. At the present time there are few studies relating to the function of these molecules, although homotypic adhesion appears to occur, and it is likely that such studies will shed light on the pathogenesis of myeloma.