Correlation Between Hippocampus MRI Radiomic Features and Resting-State Intrahippocampal Functional Connectivity in Alzheimer's Disease
Correlation Between Hippocampus MRI Radiomic Features and Resting-State Intrahippocampal Functional Connectivity in Alzheimer's Disease
复制标题
阿尔茨海默病海马 MRI 放射学特征与静息态海马内功能连接之间的相关性
DOI：
10.3389/fnins.2019.00435
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发表时间：
2019-05-07
影响因子：
4.3
通讯作者：
Ding, Zhongxiang
中科院分区：
文献类型：
--
作者：
Feng, Qi;Wang, Mei;Ding, Zhongxiang
阿尔茨海默病（Alzheimer's disease，AD）是一种以慢性原发性记忆丧失和认知功能障碍为主要症状的神经退行性疾病。本研究旨在探讨AD患者海马内功能连接（FC）与MRI放射组学特征的相关性。本研究共纳入67例AD患者和44例正常对照（NC）。采用基于种子的静息态功能磁共振成像（rs-fMRI）方法，以双侧海马为种子行全脑FC扫描，提取双侧海马FC值。我们观察到AD患者在左侧海马功能网络的某些脑区表现出破坏性FC，包括右侧直回，右侧扣带回前回和扣带回旁回，双侧楔前叶，双侧角回和双侧枕中回。此外，在右侧海马功能网络的某些脑区，包括双侧扣带回前回和扣带回旁回、右侧背外侧上级回和右侧中央前回，检测到FC降低。采用A. K.软件最后，Pearson相关分析进行这些选定的功能和双侧海马FC值。结果表明，两个灰度游程矩阵（RLM）放射组学特征和一个灰度共生矩阵（GLCM）放射组学特征与左侧海马FC值弱相关。然而，在右侧海马中放射组学特征和FC值之间没有显著相关性。提示AD组双侧海马功能网络存在异常。这是一项前瞻性研究，揭示了AD患者的MRI放射组学特征与海马内FC之间的弱相关性。
Alzheimer's disease (AD) is a neurodegenerative disease with main symptoms of chronic primary memory loss and cognitive impairment. The study aim was to investigate the correlation between intrahippocampal functional connectivity (FC) and MRI radiomic features in AD. A total of 67 AD patients and 44 normal controls (NCs) were enrolled in this study. Using the seed-based method of resting-state functional MRI (rs-fMRI), the whole-brain FC with bilateral hippocampus as seed was performed, and the FC values were extracted from the bilateral hippocampus. We observed that AD patients demonstrated disruptive FC in some brain regions in the left hippocampal functional network, including right gyrus rectus, right anterior cingulate and paracingulate gyri, bilateral precuneus, bilateral angular gyrus, and bilateral middle occipital gyrus. In addition, decreased FC was detected in some brain regions in the right hippocampal functional network, including bilateral anterior cingulate and paracingulate gyri, right dorsolateral superior frontal gyrus, and right precentral gyrus. Bilateral hippocampal radiomics features were calculated and selected using the A. K. software. Finally, Pearson's correlation analyses were conducted between these selected features and the bilateral hippocampal FC values. The results suggested that two gray level run-length matrix (RLM) radiomic features and one gray level co-occurrence matrix (GLCM) radiomic feature weakly associated with FC values in the left hippocampus. However, there were no significant correlations between radiomic features and FC values in the right hippocampus. These findings present that the AD group showed abnormalities in the bilateral hippocampal functional network. This is a prospective study that revealed the weak correlation between the MRI radiomic features and the intrahippocampal FC in AD patients.