Survival after massive hydroxychloroquine overdose
Survival after massive hydroxychloroquine overdose
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DOI：
10.1177/0310057x0903700112
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发表时间：
2009-01-01
影响因子：
1.5
通讯作者：
Buckley, N. A.
中科院分区：
文献类型：
--
作者：
Gunja, N.;Roberts, D.;Buckley, N. A.
羟基氯喹过量很少有报道，大多数建议来自对氯喹中毒的更多经验。我们报告了两例大量羟基氯喹中毒（每例20克），均接受了高级心脏生命支持和治疗方案，包括碳酸氢钠，肾上腺素和钾。这两名患者都度过了最初的快速恶化和心血管衰竭，出院时没有后遗症。这些患者报告的非致死血清浓度最高（13.8和26.0 mg/l）。在积极纠正电解质和pH紊乱以及药物迅速分布到外周组织后，他们都表现出从骤停前的状态迅速恢复。
Hydroxychloroquine overdose is infrequently reported and the majority of recommendations come from the greater experience with chloroquine poisoning. We report two cases of massive hydroxychloroquine poisoning (20 g in each case), both of which received advanced cardiac life support and a treatment regimen consisting of sodium bicarbonate, adrenaline and potassium. Both these patients survived beyond their initial rapid deterioration and cardiovascular collapse to be discharged from hospital without sequelae. These patients had the highest reported non-lethal serum concentrations (13.8 and 26.0 mg/l). They both demonstrated rapid recovery from a pre-arrest condition, following aggressive correction of electrolyte and pH disturbance and rapid distribution of the drug to peripheral tissues.