Stress, Telomeres, and Psychopathology: Toward a Deeper Understanding of a Triad of Early Aging.
Stress, Telomeres, and Psychopathology: Toward a Deeper Understanding of a Triad of Early Aging.
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DOI：
10.1146/annurev-clinpsy-032816-045054
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发表时间：
2018-05-07
影响因子：
18.4
通讯作者：
Prather AA
中科院分区：
文献类型：
--
作者：
Epel ES;Prather AA
端粒在衰老过程中起着重要作用，并显示出与一生逆境的关系，特别是童年逆境。荟萃分析表明，精神病理学（主要是抑郁症）和较短的端粒长度之间存在可靠的关联，但这种关系的性质尚未完全了解。在这里，我们审查和评估受损的端粒生物学的证据作为精神病理学的结果或作为一个促成因素，以及慢性心理应激和受损的变稳态的重要中介作用。有证据表明，压力、端粒缩短和精神疾病之间存在三元关系，这种关系在整个生命过程中，甚至可能在几代人之间，都是积极的强化和展开的。我们回顾了遗传学和生物行为反应的作用，可能有助于缩短端粒长度，以及端粒酶水平受损的神经生物学影响。这些复杂的相互关系是很重要的，因为它们对精神和身体的共病有影响，并可能对预防和治疗抑郁症。
Telomeres play an important part in aging and show relationships to lifetime adversity, particularly childhood adversity. Meta-analyses demonstrate reliable associations between psychopathology (primarily depression) and shorter telomere length, but the nature of this relationship has not been fully understood. Here, we review and evaluate the evidence for impaired telomere biology as a consequence of psychopathology or as a contributing factor, and the important mediating roles of chronic psychological stress and impaired allostasis. There is evidence for a triadic relationship among stress, telomere shortening, and psychiatric disorders that is positively reinforcing and unfolds across the life course and, possibly, across generations. We review the role of genetics and biobehavioral responses that may contribute to shorter telomere length, as well as the neurobiological impact of impaired levels of telomerase. These complex interrelationships are important to elucidate because they have implications for mental and physical comorbidity and, potentially, for the prevention and treatment of depression.