INDEXES OF BODY CELL MASS - NITROGEN VERSUS POTASSIUM
INDEXES OF BODY CELL MASS - NITROGEN VERSUS POTASSIUM
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DOI：
10.1152/ajpendo.1983.244.3.e305
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发表时间：
1983-01-01
影响因子：
--
通讯作者：
ELLIS, KJ
中科院分区：
文献类型：
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作者：
COHN, SH;VARTSKY, D;ELLIS, KJ
体内中子活化为人体成分的研究提供了强有力的工具。对133例正常人进行了全身氮(TBN)、全身K(TBK)和全身水(TBW)的测定。用中子活化法测量的总蛋白质是全身蛋白质的量度，也就是身体细胞质量的指标。Tbk也是通过核反应来衡量的，它是身体细胞质量和瘦身体质量的指标。通过隔室分析，根据TBN-TBK的组合数据，确定了肌肉和非肌肉瘦肉组织两个隔室的质量和蛋白质含量。在本研究中，N被分离为活跃代谢的身体细胞质量成分和缓慢代谢的结构成分。结果表明，TBK与主动代谢N的关系比与TBN的关系更密切，占细胞内总氮的95%。体细胞质量是由Moore首先提出的概念，它与瘦体质量的关系通过体细胞质量和体细胞质量之间的关系来表示。本研究的临床意义在于，TBK是反映体细胞质量变化的更敏感、更可靠的指标。然而，有关身体成分的最大信息是通过测量总胆红素和总胆红素获得的。
In vivo neutron activation has provided a powerful tool for research on body composition. Total-body N (TBN), total-body K (TBK), and total-body water (TBW) were measured in 133 normal subjects. TBN, measured by neutron activation, is a measure of total-body protein, an index of body cell mass. TBK, also measured by a nuclear reaction, is an index of body cell mass as well as lean body mass. The mass and protein content of 2 compartments, muscle and nonmuscle lean tissue, were determined from the combined TBN-TBK data by compartmental analysis. In this study, N was separated into the actively metabolizing body cell mass component and the slowly metabolizing structural component. The TBK, which is 95% intracellular, was found to be more closely related to the actively metabolizing N than to TBN. The relationship of body cell mass, a concept originally proposed by Moore, to lean body mass, is shown through the relationship of TBN and TBK. The clinical significance of this study is that TBK is the more sensitive and reliable indicator of changes in body cell mass. Maximum information on body composition, however, is obtained by the measurement of both TBK and TBN.