QUINONE CHEMISTRY AND TOXICITY
QUINONE CHEMISTRY AND TOXICITY
复制标题
DOI：
10.1016/0041-008x(92)90273-u
复制
发表时间：
1992-01-01
影响因子：
3.8
通讯作者：
GRAHAM, DG
中科院分区：
文献类型：
--
作者：
MONKS, TJ;HANZLIK, RP;GRAHAM, DG
醌在自然界中普遍存在，并且构成一类重要的天然存在的化合物，其存在于植物、真菌和细菌中，并且主要作为参与细胞呼吸和光合作用的电子传递链的组分起作用。人类在临床上可通过饮食或空气污染物接触醌类。鉴于人类不可避免地接触到醌类化合物以及醌类化合物的固有反应性，大量的研究集中在这些化合物的化学和生物化学毒理学上。事实上，醌类已被广泛用作研究化学诱导毒性的细胞机制的模型。本文综述了在1991年2月举行的第30届毒理学学会年会上题为“醌化学与毒性”的专题讨论会的发言。专题讨论会的重点是醌类的生物有机化学、醌类在形成各种毒性方面的作用及其潜在的作用机制。Bob Hanzlik首先概述了醌的物理和化学性质，以及这些性质如何与其生物反应性相关。Gerry Cohen随后讨论了醌氧化还原循环和大分子芳基化在醌介导的毒性中的相对重要性。Terrence Monks提供的证据表明，一些醌硫醚具有生物活性，这种硫醚可能是造成各种醌介导的毒性的原因。Dave Ross讨论了DT黄递酶在激活和排毒中可能发挥的作用-
Quinones are ubiquitous in nature and constitute an important class of naturally occurring compounds that are found in plants, fungi, and bacteria and that function primarily as components of the electron transport chains involved in cellular respiration and photosynthesis. Human exposure to quinones can occur clinically, via the diet or via airborne pollutants. In view of the inevitable human exposure to quinones and the inherent reactivity of quinones, a sub stantial amount of research has focused on the chemistry and biochemical toxicology of these compounds. Indeed, quinones have been employed extensively as models to study cellular mechanisms of chemical-induced toxicity. This review summarizes the presentations of a symposium held at the 30th annual meeting of the Society of Toxicology, held in February 199 1 under the title “Quinone Chemistry and Toxicity.” The symposium focused on the bioorganic chemistry of quinones, the role of quinones in the development of a variety of toxicities, and their potential mechanisms of action. Bob Hanzlik opened the proceedings by presenting an overview of the physical and chemical properties of quinones and how these properties may, or may not, relate to their biological reactivity. Gerry Cohen followed with a discussion of the relative importance of quinone redox cycling and macromolecular arylation in quinone-mediated toxicities. Terrence Monks presented evidence demonstrating that a number of quinone-thioethers possess biological activity and that such thioethers may be responsible for a variety of quinone-mediated toxicities. Dave Ross discussed the role that DTdiaphorase may play in both activation and detox-