SIMILARITIES OF PROTEIN TOPOLOGIES - EVOLUTIONARY DIVERGENCE, FUNCTIONAL CONVERGENCE OF PRINCIPLES OF FOLDING
SIMILARITIES OF PROTEIN TOPOLOGIES - EVOLUTIONARY DIVERGENCE, FUNCTIONAL CONVERGENCE OF PRINCIPLES OF FOLDING
复制标题
DOI：
10.1017/s0033583500001724
复制
发表时间：
1980-01-01
影响因子：
6.1
通讯作者：
FINKELSTEIN, AV
中科院分区：
文献类型：
--
作者：
PTITSYN, OB;FINKELSTEIN, AV
(A)蛋白质结构的进化相似性从第一个球状蛋白质--抹香鲸肌红蛋白的三维结构被破译（Kendrew et al. 1960）算起，已经过去了20年。它的结构，现在看起来如此简单和习惯，当时似乎异常复杂。随后对溶菌酶（Blake等，1965）、核糖核酸酶（Kartha、Bello和Harker，1967）、胰凝乳蛋白酶（马修斯等，1967）、羧肽酶（Lipscomb等，1969）等蛋白质的解码，在极其复杂、错综复杂、尤其是完全不同的蛋白质结构面前，加倍地感到惊奇，甚至有些困惑。在这种背景下，令人欣慰的是，肌红蛋白和血红蛋白亚基的三维结构之间存在明显且意义深远的相似性（Perutz、Kendrew和沃森，1965年），而胰凝乳蛋白酶和其他丝氨酸蛋白酶、弹性蛋白酶（肖顿和沃森，1970年）和胰蛋白酶（Stroud、Kay和Dickerson，1972年）的结构之间也存在类似的相似性。然而，这种相似性很容易通过肌红蛋白和血红蛋白的一级结构之间以及丝氨酸蛋白酶的一级结构之间的深远同源性来解释。
(A) Evolutionary similarities of protein structures Two decades have passed from the time that the three dimensional structure of the first globular protein, sperm whale myoglobin, was decoded (Kendrew et al. 1960). Its structure, which now looks so simple and habitual, then seemed to be unusually complicated. The decoding of the subsequent proteins, lysozyme (Blake et al. 1965), ribonuclease (Kartha, Bello & Harker, 1967), chymotrypsin (Matthews et al. 1967), carboxypeptidase (Lipscomb et al. 1969) redoubled the feeling of amazement and even of some confusion before the extremely complicated, intricate and, above all, absolutely unlike protein structures. Some consolation against this background was the evident and far-reaching similarity between the three-dimensional structures of myoglobin and hemoglobin subunits (Perutz, Kendrew & Watson, 1965) and an analogous similarity between the structures of chymotrypsin and other serine proteases, elastase (Shotton & Watson, 1970) and trypsin (Stroud, Kay & Dickerson, 1972). However this similarity was easily explained by the far-reaching homology between the primary structures of myoglobin and hemoglobin and between the primary structures of serine proteases.