Mechanisms for ATP-dependent chromatin remodelling: farewell to the tuna-can octamer?
Mechanisms for ATP-dependent chromatin remodelling: farewell to the tuna-can octamer?
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DOI：
10.1016/j.gde.2004.01.007
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发表时间：
2004-04-01
影响因子：
4
通讯作者：
Owen-Hughes, T
中科院分区：
文献类型：
--
作者：
Flaus, A;Owen-Hughes, T
在基因调控过程中，依赖于ATP的染色质重塑酶作用于改变染色质结构。对驱动这些酶的ATPase马达的研究支持这样一种观点，即它们的功能是依赖于ATP的DNA转位酶，但处理能力有限。这些酶对核小体的作用导致核小体位置和结构的改变。最近的研究表明，依赖于ATP的染色质重塑也可以在核小体之间移除或交换组蛋白二聚体。这提供了一种新的方法，可以用来指导组蛋白变体的掺入。其他观察结果支持ATP依赖的重塑酶在转录周期中的作用。
ATP-dependent chromatin remodelling enzymes act to alter chromatin structure during gene regulation. Studies of the ATPase motors that drive these enzymes support the notion that they function as ATP-dependent DNA translocases with limited processivity. The action of these enzymes on nucleosomes results in the alteration of nucleosome positioning and structure. Recent studies have shown that ATP-dependent chromatin remodelling can also either remove or exchange histone dimers between nucleosomes. This provides a new means by which the incorporation of histone variants can be directed. Additional observations support roles for ATP-dependent remodelling enzymes throughout the transcription cycle.