Perinatal cerebellar injury in human and animal models.
Perinatal cerebellar injury in human and animal models.
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DOI：
10.1155/2012/858929
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发表时间：
2012
影响因子：
1.5
通讯作者：
Ferriero DM
中科院分区：
文献类型：
--
作者：
Biran V;Verney C;Ferriero DM
通过先进的新生儿脑成像，小脑损伤越来越多地被认为是早产的并发症。早产的幸存者表现出一系列长期的神经发育缺陷，其中许多可能与小脑损伤有关，包括运动功能受损，如精细运动不协调，运动顺序受损以及老年患者的认知和行为功能障碍。本文综述了人类和啮齿类动物小脑发育的形态发生和组织发生，以及早产儿小脑更易发生的损伤。大多数小脑病变是小脑出血和梗死，通常导致小脑异常和/或萎缩，但小脑病变的确切发病机制尚不清楚。已经用动物模型研究了所涉及的不同机制，主要是缺氧、缺血、感染和炎症，暴露于药物和营养不良也可诱导小脑异常。不同的模型详细分析出生前后小脑发育的各种障碍。
Cerebellar injury is increasingly recognized through advanced neonatal brain imaging as a complication of premature birth. Survivors of preterm birth demonstrate a constellation of long-term neurodevelopmental deficits, many of which are potentially referable to cerebellar injury, including impaired motor functions such as fine motor incoordination, impaired motor sequencing and also cognitive, behavioral dysfunction among older patients. This paper reviews the morphogenesis and histogenesis of the human and rodent developing cerebellum, and its more frequent injuries in preterm. Most cerebellar lesions are cerebellar hemorrhage and infarction usually leading to cerebellar abnormalities and/or atrophy, but the exact pathogenesis of lesions of the cerebellum is unknown. The different mechanisms involved have been investigated with animal models and are primarily hypoxia, ischemia, infection, and inflammation Exposure to drugs and undernutrition can also induce cerebellar abnormalities. Different models are detailed to analyze these various disturbances of cerebellar development around birth.