POEGMA-based disulfide-containing fluorescent probes for imitating and tracing noninternalization-based intracellular drug delivery
POEGMA-based disulfide-containing fluorescent probes for imitating and tracing noninternalization-based intracellular drug delivery
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基于 POEGMA 的含二硫化物荧光探针，用于模拟和追踪基于非内化的细胞内药物递送
DOI：
10.1039/c6cc00369a
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发表时间：
2016
影响因子：
4.9
通讯作者：
Wu Chuanliu
中科院分区：
文献类型：
--
作者：
Ling Yunyang;Ren Jing;Li Tao;Zhao Yibing;Wu Chuanliu
基于POEGMA的含二硫化物的荧光探针的设计和合成，以实现在复杂的氧化还原介质中和在细胞的存在下的聚合物主链内的二硫化物的（生物）还原的实时和定量分析。本研究为利用细胞外生物还原作用来递送疏水性药物提供了新的途径。
POEGMA-based disulfide-containing fluorescent probes were designed and synthesized to enable the real-time and quantitative analysis of the (bio)reduction of disulfides within the polymeric backbones in complex redox media and in the presence of cells. This study lights up the way of exploiting bioreduction in the extracellular spaces for the delivery of hydrophobic drugs.