Importance of the backbone conformation of (-)-ternatin in its fat-accumulation inhibitory activity against 3T3-L1 adipocytes
Importance of the backbone conformation of (-)-ternatin in its fat-accumulation inhibitory activity against 3T3-L1 adipocytes
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DOI：
10.1039/b818903j
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发表时间：
2009-01-01
影响因子：
3.2
通讯作者：
Uemura, Daisuke
中科院分区：
文献类型：
--
作者：
Shimokawa, Kenichiro;Miwa, Ryoka;Uemura, Daisuke
通过核磁共振光谱数据和设计的类似物的CD光谱分析，研究了分子内氢键衍生的主链构象与新型脂肪积累抑制剂(-)-ternatin的生物活性之间的关键关系。结果表明(-)-ternatin的β -turn结构是其对3T3-L1小鼠脂肪细胞有效的脂肪积累抑制作用的原因。
Key relationships between the intramolecular H-bond-derived backbone conformation and the bioactivity of the novel fat-accumulation inhibitor (-)-ternatin are examined by analyses of the NMR spectroscopic data and CD spectra of designed analogues. The results reveal that the beta-turn structure of (-)-ternatin is responsible for its potent fat-accumulation inhibitory effect against 3T3-L1 murine adipocytes.