Increased local gyrification mapped in Williams syndrome
Increased local gyrification mapped in Williams syndrome
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DOI：
10.1016/j.neuroimage.2006.06.018
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发表时间：
2006-10-15
期刊：
影响因子：
5.7
通讯作者：
Reiss, Allan L.
中科院分区：
文献类型：
--
作者：
Gaser, Christian;Luders, Eileen;Reiss, Allan L.
应用最近开发的方法以出色的空间分辨率分析外侧和内侧皮质表面数千个点的回旋，我们绘制了患有威廉姆斯综合征（WS; n=42）的受试者和年龄匹配的受试者之间皮质表面解剖结构的差异。健康受试者样本（n=40）。WS受试者在枕叶和楔叶双侧显示出增加的脑回化。左半球的差异比右半球更明显，在左侧楔前叶、扣带回后部和前部、中央旁叶和内侧额叶中，WS中增加了更多的回转区域。与WS受试者相比，健康受试者的皮质区没有明显更复杂。在侧表面上，在WS受试者和对照组中，脑回不对称的方向和模式是相似的;后脑区域在左半球有更大的脑回，而前脑区域在右半球有更大的脑回。在内侧表面上，对照组和WS个体在旋转不对称的程度和方向上存在很大差异。我们的研究结果证实并扩展了以前在全球全脑或半球水平上测量皮质复杂性的研究。在WS患者中观察到的脑回异常可能与神经元回路功能障碍有关，因此有助于伴随疾病的独特认知和行为特征。(c)2006年爱思唯尔公司All rights reserved.
Applying a recently developed method to analyze gyrification with excellent spatial resolution across thousands of points across the lateral and medial cortical surface, we mapped differences in cortical surface anatomy between subjects with Williams syndrome (WS; n=42) and an age-matched sample of healthy subjects (n=40). WS subjects showed increased gyrification bilaterally in occipital regions and over the cuneus. Differences were more pronounced in the left hemisphere than in the right, with additional regions of increased gyrification in WS in the left precuneus, posterior and anterior cingulate, paracentral and mesial frontal lobe. No cortical area was significantly more convoluted in healthy subjects relative to the WS subjects. On the lateral surfaces, the direction and pattern of gyrification asymmetries were similar in WS subjects and controls; posterior brain regions had greater gyrification in the left hemisphere, while anterior brain regions showed greater gyrification in the right hemisphere. On the medial surfaces, control subjects and WS individuals differed considerably with respect to the degree but also direction of gyrification asymmetry. Our findings confirm and extend previous studies measuring cortical complexity at the global whole-brain or hemispheric levels. The observed gyrification abnormalities in individuals with WS might be related to dysfunctions in neuronal circuits and consequently contribute to the distinct cognitive and behavioral profile accompanying the disorder. (c) 2006 Elsevier Inc. All rights reserved.