Flexibility in metabolism bestows tenacious viability on cancer
Flexibility in metabolism bestows tenacious viability on cancer
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新陈代谢的灵活性赋予癌症顽强的生命力
DOI：
10.1016/j.lfs.2018.07.008
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发表时间：
2018
期刊：
影响因子：
6.1
通讯作者：
Han Yong
中科院分区：
文献类型：
--
作者：
Xiong Yanlu;Wang Lei;Feng Yangbo;Li Xiaofei;Jia Lintao;Han Yong
癌细胞表现出不同于非转化细胞的代谢改变，这与恶性生物学特性密切相关。灵活性仍然是代谢改变的核心特征，使癌细胞能够在内外环境的挑战中生存和茁壮成长。在这篇综述中，我们总结了癌症如何灵活和适应性地重新规划其代谢。开始，癌细胞巧妙地适应新陈代谢，为无限增殖提供足够的物质和能量。此外，癌细胞利用代谢来维持适当的细胞氧化还原状态，提供存活益处而不是损害肿瘤生长。此外，癌症可以灵活地在不同的代谢类型之间切换，以应对扩张过程中的缺氧、营养缺乏和代谢抑制等恶劣条件。最后但并非最不重要的是，癌症很好地协调癌细胞或基质细胞的代谢，以获得支持并逃避免疫破坏。总之，代谢的灵活性赋予癌症不屈不挠的生存能力。探索这种可塑性将有助于我们对癌症发病机制和癌症治疗获得新的见解。
Cancer cells display altered metabolism distinct from non-transformed cells, which is correlated closely with malignant biocharacteristics. Flexibility remains the central feature of metabolic alteration, enabling cancer cells to survive and thrive in the challenge of inner and outer environments. In this review, we summarise how cancer reprogrammes its metabolism nimbly and adaptively. To begin with, cancer cells adapt metabolism cunningly to supply sufficient materials and energy for infinite proliferation. Further, cancer cells harness metabolism to maintain appropriate cellular redox status, providing survival benefit rather than impairment on tumor growth. Moreover, cancer can switch between different metabolic types flexibly to handle harsh conditions like hypoxia, nutrient deficiency and metabolic inhibition on the journey for expansion. Last but not least, cancer coordinates metabolism of cancerous or stromal cells well to gain support and escape immune destruction. In a word, metabolic flexibility confers indomitable viability on cancer. Exploring such plasticity will help us gain new insights into cancer pathogenesis and cancer therapy.