Chronic central potassium infusion prevents deoxycorticosterone-salt hypertension in rats.
Chronic central potassium infusion prevents deoxycorticosterone-salt hypertension in rats.
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慢性中枢钾输注可预防大鼠脱氧皮质酮盐高血压。
DOI：
10.1152/ajpheart.1995.268.2.h646
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Betz,AL
中科院分区：
文献类型：
--
作者：
Klarr,SA;Keep,RF;Betz,AL
虽然很久以前就已经确定脑脊液钾浓度（CSF [K]）受到非常严格的调节，但据报道，与正常血压对照组相比，通过中枢输注醛固酮造成高血压的大鼠的CSF [K]显著降低。我们研究了另一种高血压动物模型--醋酸脱氧皮质酮（DOCA）-盐大鼠中是否也存在CSF [K]减少，并假设采用微量渗透泵进行慢性脑室内（IVT）输注钾可能会减弱在这些大鼠中观察到的血压升高。没有IVT输注或对照CSF输注（0.5微升/小时的2.9 mM K，持续2周）的DOCA盐大鼠与其各自的假手术组相比，收缩压显著升高，CSF [K]显著降低。相比之下，DOCA-盐大鼠接受IVT输注与升高[K]（10，30，或150 mM）有显着降低的血压相比，那些接受控制CSF。与各自的假手术组相比，他们也没有表现出CSF [K]下降。在10和150 mM K下，DOCA盐大鼠的血压升高与假大鼠没有显着差异。在30 mM K时，DOCA-盐大鼠的血压与其假模型相比略有但显著增加，但这种增加仍然远远低于输注2.9 mM K的DOCA-盐大鼠。输注升高的[K]对假手术动物的血压没有影响。这些研究表明，改变脑钾稳态可能在DOCA盐高血压的发展中起重要作用。
Although it has long been established that cerebrospinal fluid potassium concentration (CSF [K]) is very tightly regulated, it has been reported that rats made hypertensive by central infusions of aldosterone have significantly lower CSF [K] compared with normotensive controls. We investigated whether reduced CSF [K] is also present in another animal model of hypertension, the deoxycorticosterone acetate (DOCA)-salt rat, and we hypothesized that chronic intracerebroventricular (IVT) infusion of potassium with miniosmotic pumps might attenuate the rise in blood pressure observed in these rats. DOCA-salt rats without IVT infusions or with control CSF infusions (0.5 microliter/h of 2.9 mM K for 2 wk) had a significantly increased systolic blood pressure and a significantly lower CSF [K] compared with their respective sham groups. In contrast, DOCA-salt rats receiving IVT infusions with elevated [K] (10, 30, or 150 mM) had significantly lower blood pressures compared with those receiving control CSF. They also did not exhibit decreased CSF [K] compared with their respective sham groups. At 10 and 150 mM K, the blood pressure rise in DOCA-salt rats was not significantly different from shams. At 30 mM K, there was a slight, but significant, increase in blood pressure in the DOCA-salt rats compared with their shams, but this rise was still much less than in DOCA-salt rats infused with 2.9 mM K. Infusions with elevated [K] had no effect on blood pressure in the sham animals. These studies suggest that altered brain potassium homeostasis may play an important role in the development of DOCA-salt hypertension.