Acute kidney injury: a not-so-silent disease.

Acute kidney injury: a not-so-silent disease.
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DOI:
10.1038/ki.2013.389
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发表时间:
2014-03
影响因子:
19.6
通讯作者:
Furth, Susan L.
Furth, Susan L.
中科院分区:
医学1区
文献类型:
--
作者:
Siew, Edward D.;Furth, Susan L.

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住院儿童发生急性肾损伤(AKI)的频率越来越高,尤其容易出现长期并发症。利用新的生物标记物来改善这种疾病的表型的尝试受到在广泛选择的人群中进行的无针对性测试的限制。在这里,我们回顾了Basu等人的努力。使用现成的临床信息来确定危重儿童发生严重急性KI的风险较高,以及谁可能受益于新的诊断和预后信息。
Hospitalized children are experiencing acute kidney injury (AKI) with increasing frequency and are especially vulnerable to its long-term complications. Attempts to leverage novel biomarkers to improve phenotyping of this disease are limited by untargeted testing within broadly selected populations. Here, we review efforts by Basu et al. to use readily available clinical information to identify critically ill children at higher risk for developing severe AKI and who may benefit from novel diagnostic and prognostic information.
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