REGIONAL RAT-BRAIN NORADRENALINE TURNOVER IN RESPONSE TO RESTRAINT STRESS
REGIONAL RAT-BRAIN NORADRENALINE TURNOVER IN RESPONSE TO RESTRAINT STRESS
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DOI：
10.1016/0091-3057(83)90054-0
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发表时间：
1983-01-01
影响因子：
3.6
通讯作者：
NAGASAKI, N
中科院分区：
文献类型：
--
作者：
GLAVIN, GB;TANAKA, M;NAGASAKI, N
雄性Wistar大鼠饥饿12h后，分别在常温下进行2 h的钢丝网束缚，在特制的安全带中进行2 h的仰卧束缚，或不进行束缚。检测8个脑区去甲肾上腺素及其主要代谢物MHPG-SO4[3-甲氧基-4-羟基苯乙二醇硫酸酯]的水平。同时检测血浆皮质酮和胃溃疡发生率。所有受束缚大鼠的大部分脑区MHPG-SO4水平均显著升高。受限制的动物的几个大脑区域显示NA水平下降。所有受束缚的大鼠都表现出血浆皮质酮水平升高，并有胃部损伤的迹象。与钢丝网束缚相比，仰卧位束缚在局部脑NA周转中产生了更大的变化，更多的溃疡疾病证据和更高的血浆皮质酮水平。显然，束缚形式的急性但强烈的压力会显著改变大脑NA的活性，这可能是导致应激性疾病现象的神经化学机制。
Male Wistar rats were starved for 12 h and then subjected to either 2 h of wire mesh envelope restraint at room temperature, 2 h of supine restraint in a specially constructed harness at room temperature or no restraint. Eight brain regions were examined for NA [norepinephrine] level and the level of its major metabolite, MHPG-SO4 [3-methoxy-4-hydroxy phenyl ethylene glycol sulfate]. Plasma corticosterone and gastric ulcer incidence were also measured. All restrained rats displayed marked elevations in MHPG-SO4 levels in most brain regions. Several brain regions in restrained animals showed a reduction in NA level. All restrained rats showed elevated plasma corticosterone levels and evidence of gastric lesions. Supine restraint produced greater alterations in regional brain NA turnover, greater evidence of ulcer disease and higher plasma corticosterone levels than did wire mesh restraint. Apparently, acute but intense stress in the form of restraint causes markedly altered brain NA activity, a possible neurochemical mechanism underlying the phenomenon of stress-induced disease.