Mahogany (mg) stimulates feeding and increases basal metabolic rate independent of its suppression of agouti.
Mahogany (mg) stimulates feeding and increases basal metabolic rate independent of its suppression of agouti.
复制标题
桃花心木 (mg) 刺激摄食并提高基础代谢率，与抑制刺豚鼠无关。
DOI：
10.1073/pnas.95.21.12707
复制
发表时间：
1998
影响因子：
11.1
通讯作者：
Cone,RD
中科院分区：
文献类型：
--
作者：
Dinulescu,DM;Fan,W;Boston,BA;McCall,K;Lamoreux,ML;Moore,KJ;Montagno,J;Cone,RD
Themahogany(mg) locus originally was identified as a recessive suppressor ofagouti, a locus encoding a skin peptide that modifies coat color by antagonizing the melanocyte-stimulating hormone receptor or MC1-R. Certain dominant alleles ofagouticause an obesity syndrome when ectopic expression of the peptide aberrantly antagonizes the MC4-R, a related melanocyte-stimulating hormone receptor expressed in hypothalamic circuitry and involved in the regulation of feeding behavior and metabolism. Recent work has demonstrated thatmg, when homozygous, blocks not only the ability ofagoutito induce a yellow coat color when expressed in the skin of thelethal yellowmouse (AY), but also the obesity resulting from ectopic expression ofagoutiin the brain. Detailed analysis ofmg/mg AY/aanimals, presented here, demonstrates thatmg/mgblocks the obesity, hyperinsulinemia, and increased linear growth induced by ectopic expression of the agouti peptide. Remarkably, however,mg/mgdid not reduce hyperphagia in theAY/amouse. Furthermore,mg/mginduced hyperphagia and an increase in basal metabolic rate in the C57BL/6J mouse in the absence ofAY. Consequently, althoughmahoganyis broadly required for agouti peptide action, it also appears to be involved in the control of metabolic rate and feeding behavior independent of its suppression ofagouti.
