Probiotics and intestinal health effects: a clinical perspective
Probiotics and intestinal health effects: a clinical perspective
复制标题
DOI：
10.1079/bjn2002629
复制
发表时间：
2002-09-01
影响因子：
3.6
通讯作者：
Jian, R
中科院分区：
文献类型：
--
作者：
Marteau, P;Seksik, P;Jian, R
益生菌是活的非致病性微生物，当摄入时，对宿主的健康或生理产生积极影响。我们已经批判性地分析了特定益生菌菌株在人类胃肠道疾病中疗效的证据。最好的证据可以通过避免偏倚的随机对照试验获得。已经获得了几种菌株在预防或治疗腹泻相关疾病、治疗（以及在较小程度上预防）胃肠炎和急性腹泻以及缓解乳糖不耐受方面的良好证据。我们还分析了最近在艰难梭菌或幽门螺杆菌、炎症性肠病、肠易激综合征、非溃疡性消化不良和结肠癌患者中进行的随机对照试验。
Probiotics are viable non-pathogenic micro-organisms which, when ingested, exert a positive influence on host health or physiology. We have critically analysed the evidence for the efficacy of specific probiotic strains in human gastrointestinal diseases. The best evidence can be obtained with randomised controlled trials which avoid bias. Good evidence has been obtained with several strains in the prevention or treatment of antibiotic-associated disorders, in the treatment (and to a lesser extent prevention) of gastroenteritis and acute diarrhoea and in the alleviation of lactose intolerance. We also analysed the recent randomised controlled trials performed in patients with Clostridium difficile or Helicobacter pylori, inflammatory bowel disease, irritable bowel syndrome, non-ulcer dyspepsia and colon cancer.