Widespread nociceptive maps in the human neonatal somatosensory cortex.
Widespread nociceptive maps in the human neonatal somatosensory cortex.
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新生儿躯体感觉皮层中广泛存在的伤害性图。
DOI：
10.7554/elife.71655
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发表时间：
2022-04-22
期刊：
影响因子：
7.7
通讯作者：
Fitzgerald, Maria
中科院分区：
文献类型：
--
作者：
Jones, Laura;Verriotis, Madeleine;Cooper, Robert J.;Laudiano-Dray, Maria Pureza;Rupawala, Mohammed;Meek, Judith;Fabrizi, Lorenzo;Fitzgerald, Maria
皮质地形图对于感觉刺激的空间定位和产生适当的任务相关运动反应是必不可少的。躯体感觉和伤害感觉在成人的体感（S1）皮层中被精细地映射和排列，但在婴儿时期，当疼痛行为混乱且缺乏指导时，伤害感觉地图可能不那么精细。我们使用多光电功能近红外光谱（fNIRS）比较了新生儿（n = 32）在同一皮肤区域进行有害（临床需要的足跟枪）和无害（触摸）机械刺激后S1激活的地形模式。在S1皮质内，触觉和足跟的枪会引起局部的、部分重叠的含氧血红蛋白浓度增加（Δ[HbO]），但是当触觉激活仅限于足跟区域时，枪的激活扩展到手部皮质区域。数据揭示了婴儿S1中广泛存在的皮质痛觉图谱，这与他们定向不良的疼痛行为相一致。
Topographic cortical maps are essential for spatial localisation of sensory stimulation and generation of appropriate task-related motor responses. Somatosensation and nociception are finely mapped and aligned in the adult somatosensory (S1) cortex, but in infancy, when pain behaviour is disorganised and poorly directed, nociceptive maps may be less refined. We compared the topographic pattern of S1 activation following noxious (clinically required heel lance) and innocuous (touch) mechanical stimulation of the same skin region in newborn infants (n = 32) using multioptode functional near-infrared spectroscopy (fNIRS). Within S1 cortex, touch and lance of the heel elicit localised, partially overlapping increases in oxygenated haemoglobin concentration (Δ[HbO]), but while touch activation was restricted to the heel area, lance activation extended into cortical hand regions. The data reveals a widespread cortical nociceptive map in infant S1, consistent with their poorly directed pain behaviour.
影响因子：
3.7
作者：
Donadio A;Whitehead K;Gonzalez F;Wilhelm E;Formica D;Meek J;Fabrizi L;Burdet E
通讯作者：
Burdet E