EFFECT OF AGE AND HIGH BLOOD PRESSURE ON BAROREFLEX SENSITIVITY IN MAN
EFFECT OF AGE AND HIGH BLOOD PRESSURE ON BAROREFLEX SENSITIVITY IN MAN
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DOI：
10.1161/01.res.29.4.424
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发表时间：
1971-01-01
影响因子：
20.1
通讯作者：
PETO, R
中科院分区：
文献类型：
--
作者：
GRIBBIN, B;PICKERING, TG;PETO, R
本研究旨在探讨男性61名，女性20名，年龄19-66岁，平均动脉压在70-150毫米汞柱之间，压力感受器反射敏感性与年龄和动脉压的关系。在这组选定的受试者中，年龄和动脉压之间没有相关性。使用的敏感性指数是脉搏间期的增加，它是对静脉注射苯肾上腺素引起的收缩压升高的反射性反应，并以每毫米汞收缩压上升的脉搏间期增加为单位测量。频率范围为1.9~48.9毫秒/毫米汞柱。年龄和动脉压的增加会降低压力感受器反射的敏感性。8名受试者在测试时血压正常，但过去血压升高，在相同年龄和平均动脉压的人中，他们的反射敏感性明显低于预期。年龄在40岁以下的12例高血压患者的心率明显快于年龄匹配的正常血压者，而老年高血压患者的心率与正常血压组无明显差异。
The purpose of this study was to relate baroreflex sensitivity to age and arterial pressure in 61 male and 20 female untreated subjects, aged 19-66 years, whose mean arterial pressures ranged from 70 to 150 mm Hg. In this selected group of subjects there was no correlation between age and arterial pressure. The index of sensitivity used was the increase in pulse interval which occurs reflexly in response to a rise in systolic pressure induced by the intravenous injection of phenylephrine and is measured as the increase in pulse interval in milliseconds per mm Hg rise in systolic blood pressure. It ranged from 1.9 to 48.9 msec/mm Hg. Increasing age and arterial pressure act independently to reduce baroreflex sensitivity. Eight subjects who had normal blood pressure at the time of testing but whose pressure had been elevated in the past, had reflex sensitivities significantly less than expected in persons of the same age and mean arterial pressure. The heart rate in these subjects was not significantly different from that in the controls; the heart rate of the 12 hypertensive subjects aged under 40 years was significantly faster than that of age-matched normotensive subjects but not that of older hypertensive subjects.