CYTOSKELETON-ASSOCIATED ANTIGENS FROM AFRICAN TRYPANOSOMES ARE RECOGNIZED BY SELF-REACTIVE ANTIBODIES OF UNINFECTED MICE
CYTOSKELETON-ASSOCIATED ANTIGENS FROM AFRICAN TRYPANOSOMES ARE RECOGNIZED BY SELF-REACTIVE ANTIBODIES OF UNINFECTED MICE
复制标题
DOI：
10.1017/s0031182000067767
复制
发表时间：
1993-11-01
期刊：
影响因子：
2.4
通讯作者：
SEEBECK, T
中科院分区：
文献类型：
--
作者：
MULLER, N;IMBODEN, M;SEEBECK, T
来自不同品系的未感染小鼠的血清以及来自无菌动物的血清含有至少与两种锥虫蛋白I/6和MARP1发生特异性反应的抗体。这些抗体群对各自的蛋白质具有高度的特异性，与超免疫抗体具有相似的亲和力，并包括IgM和Ig G亚型。针对交叉反应的锥体蛋白I/6产生的超免疫抗体在小鼠3T6细胞中检测到一种60 kDa的蛋白，它是成纤维细胞细胞骨架的组成部分。
Serum from uninfected mice of different strains, as well as from germ-free animals, contains antibodies which react specifically with at least two trypanosomal proteins, I/6 and MARP1. These antibody populations are highly specific for the respective proteins, are of similar affinity as hyperimmune antibodies, and consist of IgM as well as IgG isotypes. Hyperimmune antibody raised against the cross-reacting trypanosomal protein I/6 detects a 60 kDa protein in mouse 3T6 cells, which is a component of the fibroblast cytoskeleton.