CIRCULATORY DYNAMICS DURING COLD PRESSOR TEST
CIRCULATORY DYNAMICS DURING COLD PRESSOR TEST
复制标题
DOI：
10.1016/0002-9149(65)90007-x
复制
发表时间：
1965-01-01
影响因子：
2.8
通讯作者：
ROGOW, E
中科院分区：
文献类型：
--
作者：
GREENE, MA;BOLTAX, AJ;ROGOW, E
本文对10例正常血压者和8例高血压患者进行冷加压试验时的循环动力学研究。在将手浸入冰水中之前和5分钟期间进行测量。测试的最初60秒代表血管对冷刺激的反应性，而手浸泡5分钟时的血流动力学则代表循环系统对这种刺激的适应程度。然而，只有50%的高血压患者表现出血管高反应性，即，血压升高20/20毫米汞柱或更高。此外，高血压组和正常血压组的升压反应在数量上相似。这些数据表明，冷刺激的升压反应是不改变高血压。冷加压试验代表了广泛的刺激（神经源性）的心血管系统的多个组成部分，其定量和定性方面是不可预测的临床基础上，是类似的高血压和正常血压的个人。除了加压反应之外，这种刺激期间的主要心脏动力学变化还包括外周动脉阻力增加、心率增加导致的心输出量增加以及肺动脉压增加。冷适应几乎普遍存在，通常涉及加压反应的逐渐减弱，以及对持续（冷）刺激负责的循环机制。这种现象在研究正常和高血压患者的心血管系统中的有用性是可以忽略不计的。
Circulatory dynamics during the cold pressor test were studied in 10 normotensive and 8 hypertensive patients. Measurements were made before and during 5 minutes of immersion of the hand in ice water. The initial 60 seconds of the test represented vascular reactivity to the cold stimulus, and the hemodynamics at 5 minutes of hand immersion represented the degree of circulatory adaptation to this stimulus.Most patients responded to the cold pressor test with statistically significant increases in blood pressure. However, only 50 per cent of hypertensive patients demonstrated vascular hyperreactivity, i.e., a rise in blood pressure of 20/20 mm. Hg or more. In addition, the pressor responses were quantitatively similar in the hypertensive and normotensive groups. These data indicate that the pressor reaction to the cold stimulus is not altered in hypertension.The cold pressor test represents a widespread stimulation (neurogenic) of multiple components of the cardiovascular system, the quantitative and qualitative aspects of which are not predictable on a clinical basis and are similar in hypertensive and normotensive individuals. Major cardiodynamic changes during this stimulus, in addition to the pressor response, include increased peripheral arterial resistance, increased cardiac output due to increased heart rate, and increased pulmonary artery pressures.Cold adaptation, an almost universal occurrence, generally involves a gradual diminution in the pressor response, and the circulatory mechanisms responsible for it, to continued (cold) stimulation. The usefulness of this phenomenon in the study of the cardiovascular system in normal and hypertensive patients is negligible.