High Prevalence of Cerebral Microbleeds at 7Tesla MRI in Patients with Early Alzheimer's Disease
High Prevalence of Cerebral Microbleeds at 7Tesla MRI in Patients with Early Alzheimer's Disease
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DOI：
10.3233/jad-2012-120364
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发表时间：
2012-01-01
影响因子：
4
通讯作者：
Biessels, Geert Jan
中科院分区：
文献类型：
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作者：
Brundel, Manon;Heringa, Sophie M.;Biessels, Geert Jan
阿尔茨海默病（AD）患者磁共振成像（MRI）上微出血的患病率低于其假定的病理相关性脑淀粉样血管病。我们用超高场强7特斯拉MRI检查了18例早期AD或轻度认知障碍（MCI）患者和18例非痴呆对照，以评估微出血的实际患病率是否高于目前报道的水平。在78%的MCI/AD患者和44%的对照组中观察到一个或多个微出血（p = 0.04）。7 Tesla MRI显示MCI/AD患者存在微出血可能是规律，而不是例外。
The prevalence of microbleeds on magnetic resonance imaging (MRI) in patients with Alzheimer's disease (AD) is lower than that of its presumed pathological correlate, cerebral amyloid angiopathy. We examined 18 patients with early AD or mild cognitive impairment (MCI) and 18 non-demented controls with ultra-high field strength 7Tesla MRI, to assess if the actual prevalence of microbleeds could be higher than is currently reported. One or more microbleeds were visualized in 78% of the MCI/AD patients and in 44% of the controls (p = 0.04). 7Tesla MRI shows that presence of microbleeds may be the rule, rather than exception in patients with MCI/AD.