Altered functional connectivity in children with mild to moderate TBI relates to motor control.
Altered functional connectivity in children with mild to moderate TBI relates to motor control.
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DOI：
10.3233/prm-150349
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发表时间：
2015
影响因子：
1.9
通讯作者：
Suskauer SJ
中科院分区：
文献类型：
--
作者：
Risen SR;Barber AD;Mostofsky SH;Suskauer SJ
静息状态功能磁共振成像（rs-fMRI）连接的功能相关改变已被确定在成人创伤性脑损伤（TBI）。我们评估了TBI儿童的rs-fMRI连接，并探讨了连接改变与神经功能测量之间的关系。在14名儿童TBI后和14名年龄，性别和惯用手相匹配的对照组中获得了RS-fMRI。分别评估默认模式网络（DMN）和背侧注意网络（DAN）的全脑连接;组间对比确定了TBI和对照组之间连接改变的区域。在TBI儿童中，检查了连接改变区域与相关功能测量表现之间的关系。与对照组相比，TBI儿童的DMN和右侧背侧运动前皮层（RdPM）之间以及DAN和双侧感觉运动皮层（SM 1）之间的连接性显著增强。在TBI儿童中，更大的DMN-RdPM连接与更差的运动表现相关，而更大的DAN-LSM 1连接与更好的运动表现相关;此外，DMN-RdPM和DAN-LSM 1连接呈负相关。Rs-fMRI显示与对照组相比，TBI儿童的连接发生了显着改变。儿童TBI后，连接改变的模式出现分歧，与DMN运动网络连接增加与更差的运动控制，而增加的DAN运动网络连接出现补偿。
Functionally relevant alterations in resting state fMRI (rs-fMRI) connectivity have been identified in adults with traumatic brain injury (TBI). We evaluated rs-fMRI connectivity in children with TBI and explored the relationship between altered connectivity and measures of neurological function. Rs-fMRI was obtained in 14 children after TBI and 14 controls matched for age, sex, and handedness. Whole-brain connectivity was evaluated separately for the default mode network (DMN) and dorsal attention network (DAN); Between-group contrasts identified regions with altered connectivity between TBI and control cohorts. In children with TBI, the relationships between regions of altered connectivity and performance on relevant functional measures were examined. Compared to controls, children with TBI showed significantly greater connectivity between DMN and right dorsal premotor cortex (RdPM) and between DAN and bilateral sensorimotor cortex (SM1). In children with TBI, greater DMN-RdPM connectivity was associated with worse motor performance whereas greater DAN-LSM1 connectivity was associated with better motor performance; furthermore, DMN-RdPM and DAN-LSM1 connectivity were negatively correlated. Rs-fMRI reveals significant altered connectivity in children with TBI compared to controls. After TBI in children, patterns of altered connectivity appear divergent, with increased DMN-motor network connectivity associated with worse motor control whereas increased DAN-motor network connectivity appears compensatory.