Fetal hydrops in experimental obstructive uropathy resolves after vesicostomy formation: is this cause and effect?
Fetal hydrops in experimental obstructive uropathy resolves after vesicostomy formation: is this cause and effect?
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实验性梗阻性尿路病中的胎儿水肿在膀胱造口术形成后消失：这是因果关系吗？
DOI：
10.1007/s00383-004-1257-9
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发表时间：
2004
影响因子：
1.8
通讯作者：
Koonosuke Nakada
中科院分区：
文献类型：
--
作者：
H. Kitagawa;K. Pringle;J. Koike;J. Zuccollo;Yuriko Sato;Hideaki Sato;T. Aoba;Y. Seki;M. Wakisaka;Koonosuke Nakada
梗阻性尿路病和积水的关联是罕见的，但往往是致命的。在我们的梗阻性尿路病胎羊模型中观察到水肿。我们在造成梗阻后21天建立了膀胱羊膜分流术，以探讨解除梗阻对积水的影响。胎羊在妊娠60天时进行尿道和脐尿管结扎。我们在12只羔羊中创建了膀胱造口术（雌性）或尿道造口术（雄性），以在创建梗阻后21天释放压力。胎儿在足月（145天）时分娩，取出尿路进行组织学检查。6个胎儿在膀胱造口术时有严重积水（A组），6个胎儿没有积水（B组）。A组仅有2只羔羊存活（33%），B组有4只羔羊存活（66%）。A组3只羔羊流产，1只死胎。B组2只羔羊流产。在我们的胎羊模型中，水肿似乎与大量尿腹水有关。我们假设尿腹水和积水之间存在联系。膀胱造口术，通过绕过梗阻，可以让羔羊从积水中恢复。然而，在梗阻形成后21天，积水造成的损害可能是不可逆的。
The association of obstructive uropathy and hydrops is rare but often fatal. Hydrops has been observed in our fetal lamb model with obstructive uropathy. We created a vesicoamniotic shunt 21 days after creating the obstruction to explore the effect of relieving the obstruction on the hydrops. Fetal lambs underwent urethral and urachal ligation at 60 days gestation. We created a vesicostomy (female) or urethrostomy (male) in 12 lambs to release the pressure 21 days after creating the obstruction. The fetuses were delivered at term (145 days), and the urinary tract was removed for histological examination. Six fetuses had severe hydrops at the time of the vesicostomy (group A), and six had no hydrops (group B). Only two lambs from group A survived (33%), and four lambs survived from group B (66%). Three lambs miscarried, and one was stillborn from group A. Two lambs from group B miscarried. In our fetal lamb model, hydrops appears to be associated with massive urinary ascites. We hypothesize that a connection exists between urinary ascites and hydrops. Vesicostomy, by bypassing the obstruction, may allow the lambs to recover from their hydrops. However, it is possible that by 21 days after creation of the obstruction, the damage created by the hydrops is irreversible.
用于膜片钳的上皮基底外侧膜的非酶制剂。
DOI：
10.1152/ajpcell.1990.258.6.c1159
发表时间：
1990
期刊：
The American journal of physiology
影响因子：
--
作者：
Wehner,F;Garretson,L;Dawson,K;Segal,Y;Reuss,L
通讯作者：
Reuss,L