Extracellular matrix assembly: a multiscale deconstruction.
Extracellular matrix assembly: a multiscale deconstruction.
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DOI：
10.1038/nrm3902
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发表时间：
2014-12
期刊：
影响因子：
--
通讯作者：
Weaver VM
中科院分区：
文献类型：
--
作者：
Mouw JK;Ou G;Weaver VM
细胞外基质（ECM）的生化和生物物理特性决定了组织特异性的细胞行为。与每个组织的ECM相关的分子，包括胶原、蛋白聚糖、层粘连蛋白和纤维连接蛋白，以及它们的组装方式决定了最终ECM的结构和组织。该产品是一种特殊的ECM特征，由独特的成分和地形特征组成，既反映又促进了组织的功能要求。
The biochemical and biophysical properties of the extracellular matrix (ECM) dictate tissue-specific cell behaviour. The molecules that are associated with the ECM of each tissue, including collagens, proteoglycans, laminins and fibronectin, and the manner in which they are assembled determine the structure and the organization of the resultant ECM. The product is a specific ECM signature that is comprised of unique compositional and topographical features that both reflect and facilitate the functional requirements of the tissue.