Ultrasensitive Negative Feedback Control: A Natural Approach for the Design of Synthetic Controllers.
Ultrasensitive Negative Feedback Control: A Natural Approach for the Design of Synthetic Controllers.
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DOI：
10.1371/journal.pone.0161605
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Bates DG
中科院分区：
文献类型：
--
作者：
Montefusco F;Akman OE;Soyer OS;Bates DG
合成生物学的许多最重要的潜在应用需要能够设计和实现高性能反馈控制系统，该系统可以准确调节细胞内多种分子物种的动态。在这里，我们认为，基于超灵敏响应动力学与负反馈相结合的设计策略的使用代表了解决该问题的自然方法，充分利用了细胞信息处理的强非线性性质。我们认为，这种反馈机制可以解释在最广泛研究的生物分子反馈系统之一——酵母渗透调节反应网络中观察到的适应性反应。基于对此类系统的分析，我们发现与控制工程领域数学系统理论的一个著名分支（称为滑模控制）有很强的联系。这些见解使我们能够制定设计指南，为合成生物系统的反馈控制器的构建提供信息。
Many of the most important potential applications of Synthetic Biology will require the ability to design and implement high performance feedback control systems that can accurately regulate the dynamics of multiple molecular species within the cell. Here, we argue that the use of design strategies based on combining ultrasensitive response dynamics with negative feedback represents a natural approach to this problem that fully exploits the strongly nonlinear nature of cellular information processing. We propose that such feedback mechanisms can explain the adaptive responses observed in one of the most widely studied biomolecular feedback systems—the yeast osmoregulatory response network. Based on our analysis of such system, we identify strong links with a well-known branch of mathematical systems theory from the field of Control Engineering, known as Sliding Mode Control. These insights allow us to develop design guidelines that can inform the construction of feedback controllers for synthetic biological systems.