Photomagnetic Control of Nanoparticles with Radical Pair System : A Promising New Area of Liposomal Drug-Delivery System
Photomagnetic Control of Nanoparticles with Radical Pair System : A Promising New Area of Liposomal Drug-Delivery System
复制标题
自由基对系统对纳米粒子的光磁控制：脂质体药物递送系统的一个有前途的新领域
DOI：
10.1109/tmag.2018.2868820
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发表时间：
2019
影响因子：
2.1
通讯作者：
Mikio Ohuchi
中科院分区：
文献类型：
--
作者：
Hidenori Nakagawa;Mikio Ohuchi
已经开发了大量的技术来研究磁性纳米颗粒在药物递送系统中的生物医学工程应用。本论文研究了一种新型的药物释放技术--磁性控制的脂质体纳米粒。使用永磁体（0.25 T）或空心线圈系统（40 mT）进行磁场暴露。在暴露于静电场下，脂质体膜中的抗癌荧光素（FM）被325 nm的发射波长激发。为了比较药物释放电位与磁场对模型膜中FM行为的影响，我们测量了激发后在314，260和370 nm处吸光度的光谱变化。从本文制备的脂质体的总体结果来看，在激发后20 min内，药物释放的逐渐增加与平衡的自由基对机制的水平系统间交叉相对一致。关于具有磁场效应的释放，使用0.25 T的均匀场获得的释放率比在0 T下获得的释放率更广泛，约为67%-75%。我们的系统可以提供临床性能和低侵入性之间的最佳平衡。我们相信磁场非常适合温和地控制化学反应。
A large number of techniques have been developed to investigate magnetic nanoparticles for biomedical engineering applications to drug-delivery systems. In this paper, we carried out research into a new drug-release technology using liposomal nanoparticles equipped with magnetic controls. Exposures to magnetic fields were carried out using a permanent magnet (0.25 T) or an air-cored coil system (40 mT). Under exposure to the static field, anticancer flutamide (FM) in the liposomal membrane was excited by an emission wavelength of 325 nm. To compare the drug-release potentials with magnetic field effects on the behavior of FM in the model membranes, we measured the spectral changes with absorbance at 314, 260, and 370 nm after the excitation. Judging from the overall result of our liposomes prepared in this paper, up to 20 min after the excitation, the gradual increases in the drug-releases were relatively consistent with anlevel intersystem crossing for a radical pair mechanism in equilibrium. Concerning the releases with magnetic field effects, the release rates obtained using a homogenous field of 0.25 T were more extensive on the order of 67%-75%, than those obtained at 0 T. Our system may provide the best possible balance between clinical performance and low invasivity. We believe the idea that magnetic fields are extremely suitable for the gentle control of chemical reactions.