Evidence for a hypothalamothalamocortical circuit mediating pheromonal influences on eye and head movements.
Evidence for a hypothalamothalamocortical circuit mediating pheromonal influences on eye and head movements.
复制标题
下丘脑皮质回路介导信息素影响眼睛和头部运动的证据。
DOI：
10.1073/pnas.92.9.3898
复制
发表时间：
1995
影响因子：
11.1
通讯作者：
Swanson,LW
中科院分区：
文献类型：
--
作者：
Risold,PY;Swanson,LW
同时离子电渗注射顺行示踪剂菜豆白细胞凝集素和逆行示踪剂荧光金的方法被用来表征在大鼠下丘脑丘脑皮质通路结束的区域被认为是调节注意力机制的眼睛和头部运动的方式。相关的下丘脑内侧核接收来自杏仁核的信息素信息，并投射到丘脑连合核和前内侧核的特定部分，然后投射到压后区（或内侧视觉皮层）的特定外侧部分。该皮质区接受来自丘脑外侧后核的会聚输入，并投射到上级丘。与海马结构的双向连接表明，该回路中的活动受到先前经验的影响。与基底神经节回路惊人的相似之处。
A method for simultaneous iontophoretic injections of the anterograde tracer Phaseolus vulgaris leukoagglutinin and the retrograde tracer fluorogold was used to characterize in the rat a hypothalamothalamocortical pathway ending in a region thought to regulate attentional mechanisms by way of eye and head movements. The relevant medial hypothalamic nuclei receive pheromonal information from the amygdala and project to specific parts of the thalamic nucleus reuniens and anteromedial nucleus, which then project to a specific lateral part of the retrosplenial area (or medial visual cortex). This cortical area receives a convergent input from the lateral posterior thalamic nucleus and projects to the superior colliculus. Bidirectional connections with the hippocampal formation suggest that activity in this circuit is modified by previous experience. Striking parallels with basal ganglia circuitry are noted.